ID A0A3P8VHY2_CYNSE Unreviewed; 1163 AA.
AC A0A3P8VHY2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Rho GTPase-activating protein 7 {ECO:0000256|ARBA:ARBA00014465};
DE AltName: Full=Rho-type GTPase-activating protein 7 {ECO:0000256|ARBA:ARBA00030675};
DE AltName: Full=START domain-containing protein 12 {ECO:0000256|ARBA:ARBA00032733};
DE AltName: Full=StAR-related lipid transfer protein 12 {ECO:0000256|ARBA:ARBA00030542};
GN Name=DLC1 {ECO:0000313|Ensembl:ENSCSEP00000013937.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000013937.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000013937.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000013937.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
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DR RefSeq; XP_008315337.1; XM_008317115.2.
DR AlphaFoldDB; A0A3P8VHY2; -.
DR Ensembl; ENSCSET00000014099.1; ENSCSEP00000013937.1; ENSCSEG00000008933.1.
DR GeneID; 103383815; -.
DR CTD; 10395; -.
DR GeneTree; ENSGT00950000183061; -.
DR OrthoDB; 2883046at2759; -.
DR Proteomes; UP000265120; Chromosome 9.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04375; RhoGAP_DLC1; 1.
DR CDD; cd08869; START_RhoGAP; 1.
DR Gene3D; 1.10.287.2070; -; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR12659:SF2; RHO GTPASE-ACTIVATING PROTEIN 7; 1.
DR PANTHER; PTHR12659; RHO-TYPE GTPASE ACTIVATING PROTEIN; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50848; START; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 717..927
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 999..1138
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
FT REGION 120..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..271
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..578
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1163 AA; 129421 MW; 71796DA8F288F3E2 CRC64;
MILTQIEAKE ACTWLRAAGF PQYAQLYEDA LFPIDISSVT RDHDFLDRDA IEALCRRLNT
LNKCALMRLE ISPQRKRSED SDEDELCAIS GRWTFQRDSK RWSRMEELDV FSTLSMDDKE
ASSFPKDHVP QKGKHVLHEG NSSESVLTDL SEQPEVVSIH SSGSGGRGEE KGHGATLVNE
SAPAGATRAS SVTSMCSSSG TGGSGCANED SLSDGLPPSP LESLGQFTFD MKTGIVGLGG
NMERGSESSK STRSRAKSFL KRMESLRLRS SSTSKRKKKG SITGGKIEIS GPVIKEGLDD
DKLRRLNCVD IPSISFHQNL NHHRNPTQTM TLNRNRSVSY STQTSNGSTG STGSSQSEAS
SGSAVSTPSP VTRARSHSTA AGSSKRGGMY LEGFDPLSIL QQTSDRQPKP PPNSSNAFNC
PATNGMTVHE QNHKNNYSYQ SNGGELGEEE EEEDEGMLYF YLPEGHKPGT FPKALEDGSS
RNNNGIDNGN LVVLRGRQSR RQRRGSSGSV DSRLSFYDNV PYTEREEEVE EEGDEGKLEE
VLKHVSGLKR FNAWSEAVVG EEEEEEEEDE EEEGDSDSAL DSASPCPSSP LQNRLEETEN
GSDQDSTGNP LGEGEEGMRE RRDSGVGASL TRTSRPQKLR WPSFQNSHRP SLASAQLQIS
CQSVLQMNLL QKLSLLQLTA LLEKHTPANK HGFSWAVPKF MKRIKVRDYK DRNVFGVPLQ
VIVQRTGQPL PQGIQQAMRF LRNQCLDQVG LFRKSGVKSR IQALRQMNEA SGADGGGVSY
EGQSAYDVAD MLKQYFRDLP EPLLTSKLSE TFLQIYQYMP KELRLQAARA AVLLLPDENR
EALRTLLCFL SDVTASVAEN QMTPTNLAVC LAPSLFHLNT LRRKESSSPR VMNRKQILGK
PDQKDLNENL AATHGVAHMI QECRKLFRIP EEMNRCRNSY MEQALLPRCI KDLCDEQAGN
GGYRTYLRNH LDALLKEAKD KFRGYDSCST PEQAELACRK VHDGFPLRQW KVTIEVPASP
EEVLTRVLRE QGHWDEDLLE SRVVESLDDK MEVYQYVRNT MAPHPTRDHV VLRSWVTDLP
KGACALVCTS VDHEGAPVVG VRANVLTSRY FIEPCGSNKS RLTHISRIDC RGRFPEWYNK
LYGHLCAAEV VRIRESFSAP LDK
//
