ID A0A3P8VI81_CYNSE Unreviewed; 1069 AA.
AC A0A3P8VI81;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Importin 4 {ECO:0000313|Ensembl:ENSCSEP00000014983.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000014983.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000014983.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000014983.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3P8VI81; -.
DR STRING; 244447.ENSCSEP00000014983; -.
DR Ensembl; ENSCSET00000015162.1; ENSCSEP00000014983.1; ENSCSEG00000009606.1.
DR GeneTree; ENSGT00550000075074; -.
DR InParanoid; A0A3P8VI81; -.
DR OMA; VMPRIRH; -.
DR Proteomes; UP000265120; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR PANTHER; PTHR10527:SF6; IMPORTIN-4; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SMART; SM01349; TOG; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 23..89
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
FT REPEAT 888..926
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REGION 615..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..637
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1069 AA; 118318 MW; 0C2142688FC8DF33 CRC64;
MTEELERFLL QLTEPDNAVI QQATEQLKQA FKQPAIIPAL CAVMTGSQNQ QIRQSAAVIL
RMRVKKQWSK IMPNDRESLK AVVLQAFVQE TEHTVQHSLS QLCAMLVKHE TPERWPALLQ
FLNDATKSTN PQERQRTACM KIIQSNQTPP SKPHYCQLLQ LFSTVLRDLS NPTALYYCIL
SITTITAYSG TEEMNPMRAI IPSLITALKH LIKADQDKAS EAMEVLNELI ECEVSIIVPH
VAEIVRFCLE VGIDTTHSDS LRVKALSCIT FLVKLKSKAL LKEKLLNPIL QAIFPILTAA
PPPGEQDPED DEDVIDTMAL HMPPEKLFQQ LMPLTQACLA SENPYQRKGG LLCLAVLAEG
CADHIRTKML SPMLQAVCQS LSDSNQVVRC AGLFALGQFS EHLQPEVSKY CSELMPLLLG
YLSSLNDAKV GHITKAFYAL ENFMENLGSD IEPYLPTLME TMFSALNNTE NFKIRELAVS
AIGAIANAAK ELLVPYFPPI IESLKGFLTA TAEEMRSLQT QSLDTLSVLA RTIGKDVFSP
LAAECVQLGL NLTDTIDDPD LRRCTYCLYS AISTVSPECL TPHLTAITTV MLHALKSNEG
ITPHLEEDKT FVLLDDEEEN EETDEKDIDD FTDDEPKPDV EDITGFSVEN AYIDEKEDAC
DALGEIAFNT GIAFQEFLES SFQEVYEMRD YPHEDVRRAA FSAMGQFCRA QHKVWKENQT
ESNHHALMKL LELVMPVLLE TVRTEPEREV AMAIVESMNN VIKSCKGEVF KNPTRLKEVC
FVIRDLLKKK MVCQDGGDDA DDEEQQAEYD AMLQEYAGEG IPLLAASVPA DSFAPFLNDL
LPLIMSKAKT SCTEAERSFS LGTIGEILQA LVSVPGGRGL AGRLSNRLLP VLVAGVKDRD
AEVRNNSVFG LGCLAEAAGP IVVSDYPMML SVFSNLLAKE TDLSVIDNLC GALCRMITGN
IDAVPLEQVV PALVARLPLK EDMEENKTVF NCLARLYTHS PALTVKLMKP IVAASTHILG
HKDVDEETQR TTVMLMREFA QSHSADFQAS VMSLSGEQQA KLSTAMSAS
//
