ID A0A3P8VIN6_CYNSE Unreviewed; 382 AA.
AC A0A3P8VIN6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Tumor susceptibility 101 {ECO:0000313|Ensembl:ENSCSEP00000012325.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000012325.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000012325.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000012325.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UEV
CC subfamily. {ECO:0000256|ARBA:ARBA00009594}.
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DR AlphaFoldDB; A0A3P8VIN6; -.
DR Ensembl; ENSCSET00000012472.1; ENSCSEP00000012325.1; ENSCSEG00000007946.1.
DR GeneTree; ENSGT00940000153903; -.
DR Proteomes; UP000265120; Chromosome 6.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR Gene3D; 6.10.140.820; -; 1.
DR Gene3D; 6.10.250.370; -; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR037202; ESCRT_assembly_dom.
DR InterPro; IPR017916; SB_dom.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR InterPro; IPR008883; UEV_N.
DR PANTHER; PTHR23306:SF17; TUMOR SUSCEPTIBILITY GENE 101 PROTEIN; 1.
DR PANTHER; PTHR23306; TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED; 1.
DR Pfam; PF05743; UEV; 1.
DR Pfam; PF09454; Vps23_core; 1.
DR SMART; SM00212; UBCc; 1.
DR SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS51312; SB; 1.
DR PROSITE; PS51322; UEV; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 3..146
FT /note="UEV"
FT /evidence="ECO:0000259|PROSITE:PS51322"
FT DOMAIN 314..382
FT /note="SB"
FT /evidence="ECO:0000259|PROSITE:PS51312"
FT REGION 192..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 231..304
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 192..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 382 AA; 43277 MW; 79D847B8AB5445C6 CRC64;
MAVVNETALR KMLKQYKNKD MTVREITNVI SQYKDLKPVM DAYVFNDGST RDLLSLTGTV
PVSYRGNVYN IPVCLWLLDT YPFNPPICFV KPTSAMMIKT GKHIDANGKI YLPYLHEWKP
VMSDLYGLIQ VMIVVFGEEP PVFSRPTTQA PYPSFQATGP PNGDLSLYCS SLSRGYPAYQ
YPVSNSYSAN AGPAHYPSQP SVSTAGPSRD GTIGEDTIRA SLISAVSDKL RWRMKEEMDR
AQAELDALKR TEEDLKKGHQ KLEEMVSRLD QEVSEVDRNI ELLKKKDEEL IEALEKMENQ
SENNDIDDVI VPTAPLYKQI LNLYAEENAI EDTIFYLGEA LRKGVIDLEV FLKHVRLLSR
KQFQLRALMQ KARKTAGLSD LY
//
