ID   A0A3P8VIP3_CYNSE        Unreviewed;      1679 AA.
AC   A0A3P8VIP3;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=IQ motif containing GTPase activating protein 1 {ECO:0000313|Ensembl:ENSCSEP00000015148.1};
OS   Cynoglossus semilaevis (Tongue sole).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC   Cynoglossinae; Cynoglossus.
OX   NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000015148.1, ECO:0000313|Proteomes:UP000265120};
RN   [1] {ECO:0000313|Ensembl:ENSCSEP00000015148.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   STRING; 244447.ENSCSEP00000015148; -.
DR   Ensembl; ENSCSET00000015330.1; ENSCSEP00000015148.1; ENSCSEG00000009676.1.
DR   GeneTree; ENSGT00950000183076; -.
DR   InParanoid; A0A3P8VIP3; -.
DR   Proteomes; UP000265120; Unplaced.
DR   GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR   CDD; cd21274; CH_IQGAP1; 1.
DR   CDD; cd00201; WW; 1.
DR   Gene3D; 1.20.5.190; -; 1.
DR   Gene3D; 2.20.70.10; -; 1.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR   Gene3D; 4.10.270.10; Myosin, subunit A; 1.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000593; RasGAP_C.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR001202; WW_dom.
DR   PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR   PANTHER; PTHR14149:SF15; RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP1; 1.
DR   Pfam; PF00307; CH; 1.
DR   Pfam; PF00612; IQ; 4.
DR   Pfam; PF00616; RasGAP; 1.
DR   Pfam; PF03836; RasGAP_C; 1.
DR   SMART; SM00033; CH; 1.
DR   SMART; SM00015; IQ; 4.
DR   SMART; SM00323; RasGAP; 1.
DR   SMART; SM00456; WW; 1.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF143885; RGC domain-like; 1.
DR   PROSITE; PS50021; CH; 1.
DR   PROSITE; PS50096; IQ; 4.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR   PROSITE; PS01159; WW_DOMAIN_1; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT   DOMAIN          69..184
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          703..736
FT                   /note="WW"
FT                   /evidence="ECO:0000259|PROSITE:PS50020"
FT   DOMAIN          1028..1261
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   COILED          193..220
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1679 AA;  191775 MW;  FFF0B5A2A713DE86 CRC64;
     MLQEVWEHTD WDCAQSLFRE GERRHGSMST SEETDGYRPR YGSVLDGVER LTAEEMDERR
     QQNMAYEYLC HLEEAKRWME ACLDEELPPT TELEEGLRNG VYLAKLGNFF APHTVSLKKI
     YDREQTRYKA TGLHFRHTDN VIQWLNAMSE KGLPKIFYPE TTDIYDRKNM PRCIYCIHAL
     SLYLFKLGLA PQIQDLYGKV DFTEEEINNM KSELEKYGIQ MPAFSKIGGI LANELSVDEA
     ALHAAVIAIN EAIDHGVPEG TLAAMQNPNA MLVNLDPHSA REYQDMLYQA KGEKVASSRK
     RQMENAEAER DIYDELLTQA ELQGNVNRAN VSNALKAAEE ALLSGDEDKL YEALKAMGVQ
     NLQAQNKGWY LKQLQAEREN KEQMSPGEVL TKDELQSGVD VANQIAEGYL KMLKAVERIN
     AGIRAGVAED TVEELMNPDA QLPEVYPSAA DLYQRELFSL QQQSAEGSLS HPELLVAVEM
     LSAVVLMNEA MDVGDRAALW KQLSSSVAGL SNVEDEYAQR YMDELMRLKA AAREQGSDYL
     TWNDIQACID HVNMTVQEEH ERIAAIGLIN EALDEGDPMK TLAMLQNPSA KLMDVDPSVA
     QHYHDKLLEA RREKAHETQD PSAVLWLDEI QDAILKANQD TREAFQFAQS IQTINEAVDS
     GEASQTLAAL RNSGAGLYGV TSECAQTYQD DLSKIKDEKK KEGDNGSEWV KHWVKGGHNY
     YYNLNTKEGT WVEPEGFLQN NTQLNKEDIQ SVVSGVTTAY NREQLWLANE TLITKLQARC
     RGYLVRKGLK ERIEFLKTQE PAVTRIQAHW KGYKEKKKFK DRKQFLKDHT DDAVKIQSMV
     RMHQARKKYK DRLKYFRDHI NDVIKIQAFI RANKARDDYK TLTSAEDPPM AVVRKFVHLL
     DHSDQDFQEE LELMRLREEV VTKIRSNQQL ENDLNLMDIK IGLLVKNRIT LQEVVSHSKK
     LTKKNKGQLS NMMMMNKQRG GLKALSKEKR VKLEAYQHLF YLLQTNPTYL AKLIFQMPQN
     RSTKFMDSVI FTLYNYASNQ REEYLLLRLF KTALQEEIKS KVDQMKEIVT GNPTVIKMVV
     SFHRGARGQN ALRQILAPVV KEIMEDKTLN IKTDPVDIYK SWVNQMETQT GEASKLPYDV
     TPEQAMTHEE VRTRLEASIK NMKTITDKFL SAIIVSVDKI PYGMRFISKV LKDTLQEKFP
     DATEDELLKI VGNLLYYRYM NPAIVAPDAF DIIEVSAGGA LTTEQRRNLG SVAKMLQHAA
     SNKMFLGDNA HLNPINEYLT ASYQKFRRFF LAACDVPSLE DRFNVDQYSD LVTVTKPVIY
     ISIGEIINTH TLLLDHQDAI APEHNDPIHE LLEDLGEVPT VESLIGENPL PPDDPNKELM
     GKVEVSLTLT NKFDVPGEAN TEMDARTLLL NTKRLIVDVI RFQPGETLTE ILDSTPGPEQ
     EAEYQRAMQR RAARDAKTPE KMKQVKPVVD DSLTLQGKKE KIKNNLQRLA ELGKVDPENR
     YQDLINDIAK DIRNQRRYRQ RRKAELVRLQ QTNNALNSKT NFYNVQIDSY NLYIKSCMDS
     LTSKGKLSKK QGDKAKKSKQ VSQKYTASRL HEKGVLISIE DLQPNQFKNV IFEISPSESV
     GVFDVNAKFM GVHLETLQLE YQDLLQLQYE GVAVMKLFDK ATINVNLLIF LLNKKFYGK
//