ID A0A3P8VK67_CYNSE Unreviewed; 175 AA.
AC A0A3P8VK67;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Protein Dr1 {ECO:0000256|ARBA:ARBA00018742};
DE AltName: Full=Down-regulator of transcription 1 {ECO:0000256|ARBA:ARBA00032651};
DE AltName: Full=Negative cofactor 2-beta {ECO:0000256|ARBA:ARBA00030451};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000012835.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000012835.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000012835.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NC2 beta/DR1 family.
CC {ECO:0000256|ARBA:ARBA00009245}.
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DR RefSeq; XP_008305531.1; XM_008307309.2.
DR AlphaFoldDB; A0A3P8VK67; -.
DR STRING; 244447.ENSCSEP00000012835; -.
DR Ensembl; ENSCSET00000012991.1; ENSCSEP00000012835.1; ENSCSEG00000008302.1.
DR GeneID; 103376795; -.
DR KEGG; csem:103376795; -.
DR CTD; 1810; -.
DR GeneTree; ENSGT00550000075010; -.
DR InParanoid; A0A3P8VK67; -.
DR OMA; KTIAPDH; -.
DR OrthoDB; 297906at2759; -.
DR Proteomes; UP000265120; Chromosome 2.
DR GO; GO:0017054; C:negative cofactor 2 complex; IEA:InterPro.
DR GO; GO:0140223; F:general transcription initiation factor activity; IEA:InterPro.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR InterPro; IPR003958; CBFA_NFYB_domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR042225; Ncb2.
DR PANTHER; PTHR46138; PROTEIN DR1; 1.
DR PANTHER; PTHR46138:SF1; PROTEIN DR1; 1.
DR Pfam; PF00808; CBFD_NFYB_HMF; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 12..75
FT /note="Transcription factor CBF/NF-Y/archaeal histone"
FT /evidence="ECO:0000259|Pfam:PF00808"
FT REGION 149..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 175 AA; 19377 MW; D54A82B8B84A1915 CRC64;
MASSSGNDDD LTIPRAAINK MIKETLPNVR VANDARELVV NCCTEFIHLI SSEANEICNK
SDKKTISPEH VINALESLGF ASYITEVKDV LQECKTVALK RRKASSRLEN LGIPEEELLR
QQQELFAKAR QQQAELAQQE WLQMQQAAQR AQMAAASSSA SQQAGSSQDE EDDDV
//
