ID A0A3P8VLA1_CYNSE Unreviewed; 1570 AA.
AC A0A3P8VLA1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000015069.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000015069.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000015069.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR Ensembl; ENSCSET00000015249.1; ENSCSEP00000015069.1; ENSCSEG00000009553.1.
DR GeneTree; ENSGT00940000156579; -.
DR OMA; WVQIRDD; -.
DR Proteomes; UP000265120; Chromosome 14.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR CDD; cd18666; CD1_tandem_CHD1-2_like; 1.
DR CDD; cd18661; CD2_tandem_CHD1-2_like; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 2.40.50.40; -; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR040793; CDH1_2_SANT_HL1.
DR InterPro; IPR025260; CHD1-like_C.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR023779; Chromodomain_CS.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45623:SF7; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR45623; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED; 1.
DR Pfam; PF18375; CDH1_2_SANT_HL1; 1.
DR Pfam; PF13907; CHD1-like_C; 1.
DR Pfam; PF00385; Chromo; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00298; CHROMO; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01176; DUF4208; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00598; CHROMO_1; 2.
DR PROSITE; PS50013; CHROMO_2; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 160..252
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 277..340
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 380..550
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 679..830
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 91..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 968..1010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1204..1267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1399..1570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..61
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 979..995
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1210..1224
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1239..1266
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1427..1516
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1517..1532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1570 AA; 180825 MW; 4B1B88FEE36BC287 CRC64;
SDDESDSGSR SASGSSSGSS SSSSSSSSQS GSSDSGSGSD SGSQSDSDTE KPKEKLETPN
KSNIDGTEVN KRVFSKICRC VYLMNFRNGN KSSAQRKKSK KCSSSEDDDN SYKKEASVGP
RRQATVNVSY KEDEELKTDS DDMVEVLGED VPQPEEDEFE TLERVMESRI GRKRATGSIT
TVYAVEADGE PNSNFDPNRE AGEVQYLIKW KNWAHIHNTW ETEETLKLQN VKGMKKLDNF
KKKDQEKKKW LKAASPEDIE YLNCQEELID DLHSQYQLVE RIIGHSNQKS AAGYPDYLCK
WQGLPYSECS WEDGALIAKK FQKCIDDYMN RNHSKTIPSR DCKVLKQRPR FVPMKKQASY
IGGEGLELRD YQLHSLNWMA HSWCKGHSCI LADEMGLGKT IQTISFLNYL FHEHQLYGPF
LLVVPLSTLT SWQREIQLWA PPMNVVVYLG DISSRNMIRT HEWMHVHNKK MKFNILLTTY
EILLKDKSFL GNVNWAFIGV DEAHRLKNDD SLLYKTMIDF KSNHRLLITG TPLQNSLKEL
WSLLHFIMPE KFHSWELFEE AHGKGRDSGY TSLHKELEPF LLRRVKKDVE KSLPAKVEQI
LRVEMSAIQK QYYKWILTRN YKALSKGTKG STSGFLNIMM ELKKCCNHCY LIKPPEDNGF
LNRAEALQQL IRSSGKLVLL DKLLVRLKER GHRVLIFSQM VRMLDILADY LKSRQFLFQR
LDGSIKGEMR KQALDHFNAE NSEDFCFLLS TRAGGLGINL ASADTVVIFD SDWNPQNDLQ
AQARAHRIGQ KKQVNIYRLV TKSSVEEDII ERAKKKMVLD HLVIQRMDTT GKTVLHTGAA
PSSSAPFNKE ELTAILKFGA EELFKEPEGE EQEPQEMDID EILKRAETRE NDPGPSTVGE
ELLSQFKVAN FSVMEDEELD IDSERSQRSW DDIIPEEQRR RMEEEERQKE LEEIYLLPRM
RNCAKQISFN AVEGRQSRSR RYSGSDSDSP SDRKRPKKRG RPRTIPRENI KGFSDAEIRS
LEDLIFFNGN WLDAIARDAE LVDKSEHDLK RLAETVHNGC LRTLRENPCG PDRSSGGRRG
KVKGPTFRIS GVQVNAKLVV SHEEELAPLH KAIPADPEER KKYMIPCHSK AAHFDIEWGK
EDDSSLLIGI YEYGYGSWEM IKMDPDLNLT HKLLPDDPDK KPQAKQLQTR ADYLIKLLSK
DLAKKEAQKQ ANSRKRKPRN KKSKTLKPSK IDEGAKSPSS DLPSDKKSDN EVKPEVKTEA
PERTKKACNM PVHITASGEN VPISEESEEL DQRTFSVCKE RMRPVKAALK QLDRPEKGLS
EREQLEHTRQ CLIKIGDHIT ECLKEYSNPD LIKQWRKNLW IFVSKFTEFD ARKLHKLYKH
AIKKRQENAQ VRRHIERLKD NAHQDESSRD SISSERQQPT GRIHESSSSS SKERHGSQES
HRKTTGGEPR KRPFSSFSNG KDHRERDHYR PDSRDRDRDR DRDRDRERLD RKLEDFRSSR
DHRLDMKEHS HCDQRTSYRY QADWQSEQRA SGPGPRSPYD ARSPMGHRSP FDCLSDHKST
PEQIWSSRKT
//
