ID A0A3P8VLA2_CYNSE Unreviewed; 786 AA.
AC A0A3P8VLA2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Neural precursor cell expressed, developmentally down-regulated 9 {ECO:0000313|Ensembl:ENSCSEP00000016058.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000016058.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000016058.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000016058.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}.
CC -!- SIMILARITY: Belongs to the CAS family. {ECO:0000256|ARBA:ARBA00007848}.
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DR AlphaFoldDB; A0A3P8VLA2; -.
DR Ensembl; ENSCSET00000016264.1; ENSCSEP00000016058.1; ENSCSEG00000010325.1.
DR GeneTree; ENSGT00950000183008; -.
DR Proteomes; UP000265120; Chromosome 18.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd12002; SH3_NEDD9; 1.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 1.
DR Gene3D; 1.20.120.830; Serine-rich domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR021901; CAS_C.
DR InterPro; IPR037362; CAS_fam.
DR InterPro; IPR035746; NEDD9_SH3.
DR InterPro; IPR014928; Serine_rich_dom.
DR InterPro; IPR038319; Serine_rich_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10654; CAS SCAFFOLDING PROTEIN; 1.
DR PANTHER; PTHR10654:SF20; ENHANCER OF FILAMENTATION 1; 1.
DR Pfam; PF12026; CAS_C; 1.
DR Pfam; PF08824; Serine_rich; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 3..65
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 73..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 513..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 786 AA; 86368 MW; 524265843FA05E8D CRC64;
MKYKNLMAKA LYDNVPESPE ELAFRKGDIL TVIEQNTGGL EGWWLCSLHG RQGIAPGNRL
KLLIGPMFDS QSPSPTAAAA AAQSPQGYQQ KVGSGSQGLY QVPPSLHSPQ QQSIYQVPPG
QDVYQVPPRS GLAAENTPSK VYDIPPGQMF SGQHAAARNQ GVYDVPPSQM DHRTQGVYDI
PSSSQGVYSV PPCRTNPALQ EGNYDFPQPL KHKQEGIYDV PPPVLTKSAQ SPQSPYDFLP
SAEPNAHHQQ TNTNTNEGIY DVPPPALLSG AASQRDIYDI PRCKQPLLHK NSLADRDGSK
GIYDIPAQDA RAVGDVTDGV NRLSISSTGS TRSSMSTSSS STGSSSEGRL ALDVDAAVQR
LYRLQQAVEA SVWSVQSMAS SPQWRTFPFM ERHANDVHTG LDRVRAALGD FIVFGRGATV
NATSLSDCSV HSKLRRQLGR LEDSQQILLQ IYQILENSGW SLNTLASSGK HHNKSDDLDR
FIMVSRTVPD DTKQLGSTIS ANAELLFRPS HMDGSFSNSS TPDENMLHPL TSPSSDNDNY
SEPTKPFPVP SNQDKDNLNN SEKCVKSWME DYDYVHLQGK EDFERQQKEL LEKENIIKQS
PAQLGQEQIN QFKKLEQEVI KPVENDITQW TPHQHLPGTS DSTSAPSPSA QVCARDRQLL
SFYSEQCEQH FDTLLSAVDA FFGCVSTGQP PRIFVAHSKF VILSAHKLVF IGDTLSRQAS
TPDVANRVMN SSNVLCDMLK TVVAATKTAA LNYPNTAAIQ EMVDRVTELS HHSQQFKEQL
LHMASS
//
