ID A0A3P8VMU8_CYNSE Unreviewed; 396 AA.
AC A0A3P8VMU8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Cytohesin 1 {ECO:0000313|Ensembl:ENSCSEP00000016618.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000016618.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000016618.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000016618.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8VMU8; -.
DR Ensembl; ENSCSET00000016831.1; ENSCSEP00000016618.1; ENSCSEG00000010673.1.
DR GeneTree; ENSGT00940000157519; -.
DR OMA; FRCARAP; -.
DR Proteomes; UP000265120; Chromosome 17.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd01252; PH_GRP1-like; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF340; CYTOHESIN-1; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 54..241
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 259..375
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT COILED 12..53
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 396 AA; 46201 MW; E56F25CD8693C539 CRC64;
MEAEKYVPDD LTPEEQQELE NIRRRKQELL EDIQRLKDEI AEVTSEIENL GSTEERKNMQ
RNKQVAMGRK KFNMDPKKGI QFLIENDLLK NTSDDIAQFL YKGEGLNKTA IGDYLGERDD
FNIQVLHAFV ELHEFTDLNL VQALRQFLWS FRLPGEAQKI DRMMEAFAQR YCQCNSGVFQ
STDTCYILSF AIIMLNTSLH NPNVKDKPTV ERIISMNRGI NDGGDLPEDL LRNLYDSIKN
EPFKIPEDDG NDLTHTFFNP DREGWLLKLA GGRVKTWKRR WFILTDNCLY YFEYTTDKEP
RGIIPLENLS IKEVEDKKPN CFELFIPDNK DQVIKACKTE ADGRVVEGNH TFYRISAPTA
EEKEEWMNSI KAAISRDPFY EMLAARKKKV SSMKRH
//
