ID A0A3P8VMX2_CYNSE Unreviewed; 399 AA.
AC A0A3P8VMX2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Cytohesin 1 {ECO:0000313|Ensembl:ENSCSEP00000016653.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000016653.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000016653.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000016653.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8VMX2; -.
DR Ensembl; ENSCSET00000016866.1; ENSCSEP00000016653.1; ENSCSEG00000010673.1.
DR GeneTree; ENSGT00940000157519; -.
DR Proteomes; UP000265120; Chromosome 17.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd01252; PH_GRP1-like; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF340; CYTOHESIN-1; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 57..244
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 262..378
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT COILED 15..56
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 399 AA; 46423 MW; 25988ACCB7183050 CRC64;
MVLKSEDGIV PDDLTPEEQQ ELENIRRRKQ ELLEDIQRLK DEIAEVTSEI ENLGSTEERK
NMQRNKQVAM GRKKFNMDPK KGIQFLIEND LLKNTSDDIA QFLYKGEGLN KTAIGDYLGE
RDDFNIQVLH AFVELHEFTD LNLVQALRQF LWSFRLPGEA QKIDRMMEAF AQRYCQCNSG
VFQSTDTCYI LSFAIIMLNT SLHNPNVKDK PTVERIISMN RGINDGGDLP EDLLRNLYDS
IKNEPFKIPE DDGNDLTHTF FNPDREGWLL KLAGGRVKTW KRRWFILTDN CLYYFEYTTD
KEPRGIIPLE NLSIKEVEDK KPNCFELFIP DNKDQVIKAC KTEADGRVVE GNHTFYRISA
PTAEEKEEWM NSIKAAISRD PFYEMLAARK KKVSSMKRH
//
