ID A0A3P8VMY9_CYNSE Unreviewed; 352 AA.
AC A0A3P8VMY9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Calcium homeostasis modulator 1 {ECO:0000313|Ensembl:ENSCSEP00000016673.1};
GN Name=CALHM1 {ECO:0000313|Ensembl:ENSCSEP00000016673.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000016673.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000016673.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000016673.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CALHM family.
CC {ECO:0000256|ARBA:ARBA00008497}.
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DR RefSeq; XP_008315597.1; XM_008317375.1.
DR AlphaFoldDB; A0A3P8VMY9; -.
DR STRING; 244447.ENSCSEP00000016673; -.
DR Ensembl; ENSCSET00000016886.1; ENSCSEP00000016673.1; ENSCSEG00000010717.1.
DR GeneID; 103384012; -.
DR KEGG; csem:103384012; -.
DR CTD; 255022; -.
DR GeneTree; ENSGT01030000234610; -.
DR InParanoid; A0A3P8VMY9; -.
DR OMA; KEWAVYY; -.
DR OrthoDB; 5296902at2759; -.
DR Proteomes; UP000265120; Chromosome 9.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR029569; CALHM.
DR PANTHER; PTHR32261; CALCIUM HOMEOSTASIS MODULATOR PROTEIN; 1.
DR PANTHER; PTHR32261:SF2; CALCIUM HOMEOSTASIS MODULATOR PROTEIN 1; 1.
DR Pfam; PF14798; Ca_hom_mod; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 21..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 49..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 258..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 352 AA; 40875 MW; 4E4FDAB16CCEA27A CRC64;
MDKFRMMFQF LQSNQESFMN GICGIMALAS AQMYSAFEFN CPCMPEYNYT YAIGLLIIPP
IWFFLLGFVL NNNVSVLAEE WRRPIGERRK DPSILRYMFC SVTQRSLIAP AVWVSVTLMD
GKSFLCAFSV SLDIDRFGNY SLLRGLSEVE KMKVLAKIPC KDLFEHQEIR IAASRYVKCI
SQACGWIFLL MMTFTAFLIR AIRPCFTQAA FLKTKYWSHY VDIERKMFDE TCKEHAKSFA
KICIQQYFEN MSGEMQSFHN QRSSDSDSDE DDEDIRRSDE DKLLGIRAQD DMNKVLWNWH
TCKPALALRK NYADVHENEK VNGEANGGFN GFVNGHTQDV KKKEWAVYYS KV
//
