ID A0A3P8VQ74_CYNSE Unreviewed; 3835 AA.
AC A0A3P8VQ74;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Dynein, axonemal, heavy chain 6 {ECO:0000313|Ensembl:ENSCSEP00000017378.1};
GN Name=DNAH6 {ECO:0000313|Ensembl:ENSCSEP00000017378.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000017378.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000017378.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000017378.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 244447.ENSCSEP00000017378; -.
DR Ensembl; ENSCSET00000017594.1; ENSCSEP00000017378.1; ENSCSEG00000011087.1.
DR GeneTree; ENSGT00940000154761; -.
DR InParanoid; A0A3P8VQ74; -.
DR OMA; VESFDWQ; -.
DR Proteomes; UP000265120; Chromosome 9.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF34; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 1239..1342
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1520..1658
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1867..2045
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2218..2351
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 2659..2700
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2933..2995
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3835 AA; 437756 MW; F6B1F058BF997304 CRC64;
MCQTLGLRAK SCPPSHFKTE TYPTLPQRPF SIKNGEPLDT SSVKIYEYSK DDFLMITQEG
VVSVRKDECD FVTLERWEEE YDHHCKITRI PFFSRFKKWK PFYIWRSKVR AKKFHLARDS
LRNRLFIVSQ TLSPSLIDIR KMCCQIIDTG LCQVEKNHTF TLQEFQEYQF KQQQEVDIEI
CLVQNCAFYT FFAHPWKAII TFFLSKAVTF GLQTPGYKSV KSSSLPNYKE SSSLHTSFIR
LVDYLVVNTL HTLVVNAAET ILTVLQEQVQ ETPTHAVIES WGQPPEPDTE SAESENTQVP
PMFMSELSMD SHALTFNPSE DNFQVCFFVI LCVCYFQTLE NKYTNGPDLE VIIGTDGVLQ
NIVQKIRESL KVAFDAAKVY SHMFERFRLF YKENQSLDVD AMRQQDQGLS YFEKALELYH
TEQKDAAALQ QKRHLGLLLV DKTILKEKLV SSPLHCLQVI NEMLSKLARN KLDGILAEAC
DAQFKLELNP SSTAEFASSL TFLDEIRERI VVLEEEQETV SQMYNLIKIY SVPTPPEDLV
VFATLQSSVN SLHRVIDEAV AERDTCMERF CSALHEDIMN LNREVMKNKE KSEDPQILDI
NADSSEVRRL LGEIRISVDE MQTQASTYIS YQKRFKMEET KFDTLEELTA QIRLKQLLWD
SLEEWDSLQD GWWQVGTLEQ LDLEPLNAQV TKYSKCVIQL EKDLPQNNLV PILKDKVEVM
KHRLPVITDL RNPCMKPEHW KTLESIVGTS VNVTELTVAL LENINVFSYG AEIQEVSGLA
SGEASVDAIV TKVEDVWRTT EFTVLSHGDS KDVFILGGTD EIQVLLDDSL INVSSVASSR
YVAPIKTRVE NLLKQLNLFN QTLDEWLACQ RSWLYLESIF IAPDIKRQLP AESKMFLKVD
KSWKEIMAKV KKRPNALNSA TQPDLLQTFQ QNNVLLDEIQ KCLEAYLESK RVIFPRFYFL
SNDELLKILA QTRNPQAVQP HLRKCFDAIT RLEFALMPKE PAAAAAAAAA AGTAQSVGEQ
ESIYSKDILY MISPEGEKVA LTKGLKAQGN VEDWLCKVEE AMFSSLRRLS KAAIADYQTK
SREEWVVAGH PSQVVLTISQ MMWCRDMDGC LEGDHDHFAA LQKFESINFD RLNSLAALVR
GQLPTLHRNI VTALITIDVH ARDIVTDLIR SAPQVDSRSN FEWQRQLRYY WDLDLDNCVA
KMALSSYTYG YEYLGACPRL VITPLTDRCY LCLMGALQLD LGGAPAGPAG TGKTETTKDL
AKALAIQCVV FNCSDGLDYK MMGRFFSGLA QSGAWCCFDE FNRIDIEVLS VIAQQLITIR
NAKAAKLPRF RFEGREIKLV PTCAAFITMN PGYAGRTELP DNLKALFRPI AMMVPNYALI
AEVILYSEGF ESSKVLARKM TQMYKLCSEQ LSQQDHYDFG MRAVKSVLVM AGSLKRNNPH
LSEDVVLIRA LRDSNLPKFL TDDAVLFGGI LSDLFPGVYI PEHDYGVLHS TILETLVKRN
LQPLDSMIKK VIQLYETMLV RHGVMLVGPT GGGKTTVYTI LADTLETLHQ SAHSANNSFY
QPVRTYVLNP KSVTMGELYG EVNTLTLEWR DGLMALSVRD AVSDTTDDHK WVVSDGPVDA
LWIENMNTVL DDNKMLCLAN SERIKLTPSI HMMFEVQDLA VASPATVSRC GMVYIDPDEL
KWKPYVQTWI SGLGEKFPVP VRTYLLELFE QYVEKGLQFV LKHCTQVIHQ VDISKVATLC
FLVEALLLGE GGPDLTMDFS VLNSVLCQTF VFCYLWAVAG NLTSSHWDTF DTFVRQQFED
NAHVKFPKNA TLWNFYMNFR HWPPQLEPWE KIIPPFTYNT EQPFFEMLVP TADTVRYGYL
MEKLLSVQRS VLFTGGTGVG KSVVARDLLN SIQEKAGYLP VYISFSAQSS SACTQEIIES
KLEKKRKNLL GAPTNKKVVV FVDDLNMPKL DTYGSQPPIE LLRQFQDFSG FYDRSKFFWK
EIQDMTITAA CAPPGGGRNP VTPRFIRHFS MLCLPTPSEH SLKQIFKAIL NGFLADFYQA
VKDCTAQIVD AAVEIYNRLS VDLLPTPAKS HYVFNLRDLS KCVQGILQSK PSQVRDKNQI
FRLFCHECQR VFHDRLINNQ DKTYFNTVLC EMAEKHFSID LEPSYFVDQP IIFGDFIKMG
TEKDDRVYED LTDVNKIQSV LEDYLSDYNA AFSKETKLVF FQDAIEHVAR IARIIRQERG
NALLVGVGGT GKKSLTRLAA HMCGYRCFEI ELSRGYSYDS FHEDLRQLYK MAGVEGKDMV
FLFTDTQDEL EQVLAATRPK AKEAGISEEN RDEVFQYFIS RVREKLHVVL CMSPVGDAFR
ARCRMFPSLV NCCSIDWFVQ WPREALLSVS KAFFQNVDFG SEELKRSFST MCVEIHVSVT
DMAERFYLEL RRRYYTTPTS YLELINLYLG MLEEKRQQLI LARDRIKNGL GKLLETNELV
DKMKVDLSAL EPVLKQKSTD VDALMKKLAV DQERADEVRK VVKEDEALAK VKAEDTQAIA
DDAQRDLDEA LPALESANQA LSSLDKADIS EIKVFTKPPD LVMTVMEAVC ILLSCKPDWP
SAKQLLGDAN FLRRLTDYDK DNIKPQILLK LQKYINNPDF IPEKVEKVSR ACRSMCMWVR
AMDIYARVLK EVCPKREKLA MAQVELDMTM ETLREKQEKL QEVENQIKVL QEQFDSSEQE
KETVVTTMSL TKARLVRAGK LTSALGDEQI RWEESVALYE QEIVNVVGNV FIAAACVSLT
YNTSKHTHTY IYILIPISSS FSLINILGDP FVIRQWNTEG LPRDTVSTEN GILVTEGRRW
PLMIDPQDQA NRWIRSKEAK HGLKVIKLTD PGFLRTLENA IRMGMPVLLE ELKETLDPAL
EFYMTTKMAN PHYLPEVCIK VTIINFTVTK SGLEDQLLSD VVRLESPHLE EQRNELIVRI
NADRNQLKDI EERILKLLFT SEGNILDNEE LVQTLQESKV TSEAIKQRLE EAEATELMIN
SARERYRPVA TRGSVLYFVI ASLSEIDPMY QFSLKYFKQL FNTTIETSEK STVLEKRLRI
LLDQILLSSY VNVSRGLFEQ HKLIYSFMLC VEIMRQRGEI SDEEWQFFLR GAASLQKSYA
ERPDVPWLSD FYWQMCCELH NTLPCFKGIS EEITRTHIHI NLGCFQASLN PDMYRDYVSE
LPPLTASMEF KERVVRGYWN ERLGAFQKLI LIKSFMEEKV VSAVTEFVIV NLGKQFVENP
PIDLNNLYND MTPATPLVFI LSTGSDPMGA FQRFAKERDC LDRVQSISLG QGQGPIAEKM
IHEALKSGNW VFLQNCHLAV SWMLALEELI KTFSEPDTQI HQDFRLFLSS MPTKVFPVTV
LQNSVKVTNE PPKGLRANMR RAFREISTDF FEDHVLGQQW RKIVFGICFF HAIIQERKKF
GPLGWNIRYE FNDSDRECAL LNLNLYCKDG TIPWDITYGG RVTDAWDQRC LRTILKGFFS
PNTLEPDYTY SSSGVYYAPG TDYLEEYKQY IESLPIIDDA EIFGMHENAN LAFQRQETTS
LVNTILDVNP RSSAQHGAKS NDEMVCDLAE SILTKCGVAL MCSHVNPVAS TSLLTLKKAI
AGLVVMSEEM DQMYKSFLKN QVPTHWANSS YPSLKTLASW VRDLTLRTSF IQTWITCGQP
KSFWISGFFF PQGFLTGVLQ NHARFYKLPI DELSFHYSVL PVYRDQAVTC EALQTQADDA
KMNMDDELPE PKDGVLVHGM FMDASRWDDV TMTIEDALPR VMNTMLPVVH FEPRPNYEPE
ANLYHAPLYK TSARAGTLST TGHSTNFVVT VMLPSKRPSD YWISKASALL CQLDD
//
