ID A0A3P8VQH2_CYNSE Unreviewed; 748 AA.
AC A0A3P8VQH2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Calcium-independent phospholipase A2-gamma-like {ECO:0000313|Ensembl:ENSCSEP00000016529.1};
GN Name=PNPLA8 {ECO:0000313|Ensembl:ENSCSEP00000016529.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000016529.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000016529.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000016529.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8VQH2; -.
DR Ensembl; ENSCSET00000016741.1; ENSCSEP00000016529.1; ENSCSEG00000010619.1.
DR GeneTree; ENSGT00940000154738; -.
DR OMA; PEHYWRI; -.
DR Proteomes; UP000265120; Chromosome 8.
DR GO; GO:0004620; F:phospholipase activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd07211; Pat_PNPLA8; 1.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR045217; PNPLA8-like.
DR InterPro; IPR002641; PNPLA_dom.
DR PANTHER; PTHR24185; CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA; 1.
DR PANTHER; PTHR24185:SF1; CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA; 1.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 411..606
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
FT REGION 75..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..107
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..289
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 748 AA; 82452 MW; 66527A1B7277F5B8 CRC64;
MYIVVNPFNT ISWQVSRCLN LFIFFSESRR MSRIRTTLDS VTKAVGSTDL ISKISRLKPG
GAAVSGAHVD NILVNSETPN NNSAPPSPEA IMKEEDEGGK NVAEKEQEVQ VRENSVVATK
KSKPSLLSAA NVSSSTVAKQ TIQLFQPAAL STNMDETYKT LAQHVNNYFG MTTQEERAKE
PVLIASPVAE AKIIEATTTS PSISITQNPA CGTPPSSDTP KTENATRTGP LTTTSAKKGF
TQYLSYPRPS VQSFVGSYIA PLVPKFRGDS KGNTAEKDRV PAVAAEEPAT DCKVTEKTES
EEGKVDEAKQ QLLTQRQKIT ARVGVDNRTR TLVKGLQGVG DVKLLTTRVE ELSFHLLEFP
ETRAAAVKES VLPCLLRLRQ ARDLPLQAAV REALALVGYV EPVKGRGIRV LAIDGGGTRG
LLALQTLHKL QDLTGKPVHQ LFDYICGVST GAILAFMLGI YQIPLEECEE MYRKLGSDVF
KQNVIVGTMK MGWSHAFYDS EIWENVLKER MGEGCMIESA RDPHCPKVSA VSTIVNRGLP
LKAYVFRNYR LMPGVRSHYL GDCKHKMWQA IRASSAAPGY FQEFVLGKEL HQDGGLLINN
PTALAIHECK CLWPNTPLQC VLSLGTGRYE TAGKNNTTYT SLKAKLTNVI SSATDTEEVH
TMLDALLPPD TYFRFNPYLS EDIPLNESRL EKLNFLKSEG EHYLKRNEAK LKKAASVLGQ
EKSSIQRLAE WVKLKTDMYE GLPFMSKL
//