ID   A0A3P8VQH2_CYNSE        Unreviewed;       748 AA.
AC   A0A3P8VQH2;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Calcium-independent phospholipase A2-gamma-like {ECO:0000313|Ensembl:ENSCSEP00000016529.1};
GN   Name=PNPLA8 {ECO:0000313|Ensembl:ENSCSEP00000016529.1};
OS   Cynoglossus semilaevis (Tongue sole).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC   Cynoglossinae; Cynoglossus.
OX   NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000016529.1, ECO:0000313|Proteomes:UP000265120};
RN   [1] {ECO:0000313|Ensembl:ENSCSEP00000016529.1, ECO:0000313|Proteomes:UP000265120}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24487278;
RA   Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA   Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA   Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA   Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA   Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA   Zhao Y., Schartl M., Tang Q., Wang J.;
RT   "Whole-genome sequence of a flatfish provides insights into ZW sex
RT   chromosome evolution and adaptation to a benthic lifestyle.";
RL   Nat. Genet. 46:253-260(2014).
RN   [2] {ECO:0000313|Ensembl:ENSCSEP00000016529.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3P8VQH2; -.
DR   Ensembl; ENSCSET00000016741.1; ENSCSEP00000016529.1; ENSCSEG00000010619.1.
DR   GeneTree; ENSGT00940000154738; -.
DR   OMA; PEHYWRI; -.
DR   Proteomes; UP000265120; Chromosome 8.
DR   GO; GO:0004620; F:phospholipase activity; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd07211; Pat_PNPLA8; 1.
DR   Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR045217; PNPLA8-like.
DR   InterPro; IPR002641; PNPLA_dom.
DR   PANTHER; PTHR24185; CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA; 1.
DR   PANTHER; PTHR24185:SF1; CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   PROSITE; PS51635; PNPLA; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT   DOMAIN          411..606
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000259|PROSITE:PS51635"
FT   REGION          75..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          203..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          269..289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..107
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        270..289
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   748 AA;  82452 MW;  66527A1B7277F5B8 CRC64;
     MYIVVNPFNT ISWQVSRCLN LFIFFSESRR MSRIRTTLDS VTKAVGSTDL ISKISRLKPG
     GAAVSGAHVD NILVNSETPN NNSAPPSPEA IMKEEDEGGK NVAEKEQEVQ VRENSVVATK
     KSKPSLLSAA NVSSSTVAKQ TIQLFQPAAL STNMDETYKT LAQHVNNYFG MTTQEERAKE
     PVLIASPVAE AKIIEATTTS PSISITQNPA CGTPPSSDTP KTENATRTGP LTTTSAKKGF
     TQYLSYPRPS VQSFVGSYIA PLVPKFRGDS KGNTAEKDRV PAVAAEEPAT DCKVTEKTES
     EEGKVDEAKQ QLLTQRQKIT ARVGVDNRTR TLVKGLQGVG DVKLLTTRVE ELSFHLLEFP
     ETRAAAVKES VLPCLLRLRQ ARDLPLQAAV REALALVGYV EPVKGRGIRV LAIDGGGTRG
     LLALQTLHKL QDLTGKPVHQ LFDYICGVST GAILAFMLGI YQIPLEECEE MYRKLGSDVF
     KQNVIVGTMK MGWSHAFYDS EIWENVLKER MGEGCMIESA RDPHCPKVSA VSTIVNRGLP
     LKAYVFRNYR LMPGVRSHYL GDCKHKMWQA IRASSAAPGY FQEFVLGKEL HQDGGLLINN
     PTALAIHECK CLWPNTPLQC VLSLGTGRYE TAGKNNTTYT SLKAKLTNVI SSATDTEEVH
     TMLDALLPPD TYFRFNPYLS EDIPLNESRL EKLNFLKSEG EHYLKRNEAK LKKAASVLGQ
     EKSSIQRLAE WVKLKTDMYE GLPFMSKL
//