ID A0A3P8VR34_CYNSE Unreviewed; 199 AA.
AC A0A3P8VR34;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Metalloproteinase inhibitor 2-like {ECO:0000313|Ensembl:ENSCSEP00000016769.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000016769.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000016769.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000016769.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protease inhibitor I35 (TIMP) family.
CC {ECO:0000256|ARBA:ARBA00011027}.
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DR RefSeq; XP_008327778.1; XM_008329556.2.
DR AlphaFoldDB; A0A3P8VR34; -.
DR Ensembl; ENSCSET00000016982.1; ENSCSEP00000016769.1; ENSCSEG00000010774.1.
DR GeneID; 103392824; -.
DR KEGG; csem:103392824; -.
DR GeneTree; ENSGT00940000158348; -.
DR OMA; PFGKCET; -.
DR OrthoDB; 5403389at2759; -.
DR Proteomes; UP000265120; Chromosome 17.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 3.90.370.10; Tissue inhibitor of metalloproteinase-1. Chain B, domain 1; 1.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR001820; TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR InterPro; IPR027465; TIMP_C.
DR PANTHER; PTHR11844; METALLOPROTEASE INHIBITOR; 1.
DR PANTHER; PTHR11844:SF25; NETRIN MODULE NON-TIMP TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00965; TIMP; 1.
DR SMART; SM00206; NTR; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50189; NTR; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601820-3};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR601820-1};
KW Metalloenzyme inhibitor {ECO:0000256|ARBA:ARBA00023215};
KW Metalloprotease inhibitor {ECO:0000256|ARBA:ARBA00022608};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|PIRSR:PIRSR601820-1}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..199
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018194451"
FT DOMAIN 27..144
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT BINDING 27
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="ligand shared with metalloproteinase partner"
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-1"
FT DISULFID 27..93
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 29..119
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 39..144
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 146..190
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 151..156
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 164..182
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
SQ SEQUENCE 199 AA; 22166 MW; 35A6A7D92235242A CRC64;
MTRALNIILL TLAVLLLGGL EETAEACRCS QVHPQWQFCN SDVVIKAKVV GEETVYDGTF
PVSIKYIIKK PKIFRGECQE VDAVFTPYSS ATCGVRLQTG TDYLLSGYMD SDGMHISLCG
FNVPWNSLTD TQKLGVTQHY EKGCECTIQT CFTLPCESSD PQMCVWTDMV FGVQQQADHS
SCIKRDDDTC AWYTSPQQT
//
