ID A0A3P8VR54_CYNSE Unreviewed; 1395 AA.
AC A0A3P8VR54;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=CIT {ECO:0000313|Ensembl:ENSCSEP00000016789.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000016789.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000016789.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000016789.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR Ensembl; ENSCSET00000017002.1; ENSCSEP00000016789.1; ENSCSEG00000010676.1.
DR GeneTree; ENSGT01030000234517; -.
DR Proteomes; UP000265120; Chromosome W.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR CDD; cd20814; CRIK; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22988:SF71; CITRON RHO-INTERACTING KINASE; 1.
DR PANTHER; PTHR22988; MYOTONIC DYSTROPHY S/T KINASE-RELATED; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 738..787
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 815..934
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 968..1258
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 38..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1312..1395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 210..237
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 274..560
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 653..687
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1323..1370
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1375..1395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1395 AA; 159845 MW; 5EA8BFB285CAE36E CRC64;
SKINELQEKL AKASKASSEA TDLLQIMRVA KERMERDLER LQNKEASTDS LRRRLRETED
GRKTLENQVK RLEMVETKIK DEIQSKTQQI QQMADKILEL EENLRETQAT AQRFETHLKQ
KEKLYEDKIK VLEAQMKADM ADKEMLESSQ SKYEEEVREK CSIISEQKVV RADQPGSDTI
LAANSSIYTQ KNMKAQEEMI SELRQQKFYL ESQAGKLEAQ NAKLEEHLEK ISQQEQSNKS
RVLEQEIRLR EMGLEHEEQK LEIKRQVTEL TITLQERESQ VSNLQAARHA LESRLQQAKT
ELEETTTEAE EEITVLRAHR DEIQRKFDTL RDSCAVITDL EEQLTRLTEE NAELNRQNFY
LSKQLDEASD EREDCLQLSQ DVDRLRREVA DREMHLNNQK QNLETLKTTC TMLEEQVLEL
ETLNDELMEK ERQWDTWRTT LVGEKNQAER KTREIQRLLD TEKQKRIRAE QRSSESRQDV
DQAVKEHKAE ILALQQALKD QKLRAETLTD TLNDLEKKHA MLEMNAHSLQ QKLESERDLK
QRLLEEQEKL QQQMDAQKTH IFRLTQGLQD ALDQTDLLKT ERTNLEYQLE NIQAVYSHKK
VKMEGTIGQQ TKLIDFLQAQ AHDGSKKKKG LFGRRCEDLL PVPLQYSDMK LALDKERAHC
SELEDALQKM RAELRSLREE ALQYKDQGNS SNPPSSRQQM IMSAMVKSPE HQQAPPNLAP
SQRDRERERE RVMHHSTAHR FTVGLNMRAA KCTVCLDTVH FGRQAATCLE CHALCHPKCS
PCLPSTCGMS SDCSLHLSEG LCRDKGQQLK DCSGHMHVEG WMKQPRNGKR GQAWERKFVA
LDGTKISVYE VEPREGILKP LEKFDLCLSD GEVMVHGAVG ASELPNTAKS DVPYVIKLET
RCHAPCWPGQ SIYFMAQSFP EKQRWVSVIE SVVASGRASR EKAEADAVSV SEPKLLGNSL
LKLEGDDRLD INCTLPLTDQ IVLVGSEEGL YALNVIKNSL THVPGLGSVF QIHIIKEQEK
LLMIVGDERA LCLVEIKRVK QSLAQSHLPS QSELAPYIFE TVKGCHLFSA GRVDNGSCIC
AAMPNKITIL RYNDNLNKYC IRKEIETLEP CSCIHLTSYS IIIGINKFYE IEMKQFVLDE
FLDKNDMSLA SAVFAAASHS FPIAIMQVAS SLQKEEYLLC FHEFGVFVDM YGRRSRTEEI
KWSRLPLSFA YREPYLFVTY FNSLDVVEVQ GHSTLGPTVL AQLDIPSPRY LGPAISSGAI
YLASSYQNKM RVICCNGSLI RESLELQRSG SSWGSPTKRC PPTYTEHITK RLTLGPGSHD
GLHREPSTPH RYREGRTEFR RDKSPARPLE REKSPGRVLD SRRERSPGRF GESTHAGSVR
TQLAPVNKVW DQSSV
//
