ID A0A3P8VRT1_CYNSE Unreviewed; 1595 AA.
AC A0A3P8VRT1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Kinase non-catalytic C-lobe domain containing 1 {ECO:0000313|Ensembl:ENSCSEP00000015986.1};
GN Name=KNDC1 {ECO:0000313|Ensembl:ENSCSEP00000015986.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000015986.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000015986.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000015986.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSCSET00000016189.1; ENSCSEP00000015986.1; ENSCSEG00000010219.1.
DR GeneTree; ENSGT00390000011408; -.
DR Proteomes; UP000265120; Chromosome 12.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR011019; KIND_dom.
DR InterPro; IPR029899; KNDC1.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR21560:SF0; KINASE NON-CATALYTIC C-LOBE DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR21560; VERY KIND PROTEIN; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00750; KIND; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS51377; KIND; 2.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..122
FT /note="KIND"
FT /evidence="ECO:0000259|PROSITE:PS51377"
FT DOMAIN 370..535
FT /note="KIND"
FT /evidence="ECO:0000259|PROSITE:PS51377"
FT DOMAIN 1182..1310
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1380..1595
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 212..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 957..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..554
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1595 AA; 176992 MW; 1DC861BF06CFF497 CRC64;
MEQLSDDPEG SFVPPEFDNT GSTFEGHIFS LGSTLFAALN FVIEPELEVE IGEEIQKLLE
QMQDEKPEDR PLLQEILSLA KARLYDASSA AVCRKLSSIG RRVLSIESVS PFQDGQEGTW
EARWQHQGPR CAFERLSSDK NNKDVCTDGS DKTNCLSRQQ VCRGWDSSLW SEDMEEDGLS
LADEMDCRSH NSSPVRRRAQ QRLTRVKGAL NRSCSVPDSN NPPSLSTPTH GNISIPISDL
TEIGADDHVS STSVWSNRLQ RLNRGNSCDA YTHSSTEYYE NSVDNQRSQV HQGSDETLCI
EEESTHDVLQ GERKDSTQDL ASPCSSCQDL EMAQESPENQ SPVNHNLYFT NNHMTKSMLC
LNEESQDEWI SLRELLSRCG RRLTVNELWA LCYTCLSSLQ TYIDFPAYLC LDTVYVGCEG
EVLFLKPKNI GPRDEFYLAP EYQEHGIVTE KVCVYAVAAI LWATAKFSLS PTQKLAMPRK
LKRLLLEMAK RTPIERPTII MAKKSCRDYL LGQETSAETV WNDLISRVHP PVSQPKGDED
FNLSETHHSS SEDSEQNDSS FVPMATESRL APVPGPVPYS YPVSTRLQLP EAFTSTATHF
VPIVLTNKGD SEKEGQNIEA VFQGDEEEFT TLNNEVALPE CPRPVQAETN LHTEEPLVNF
SLKTLTSTSS SNNTPASSCL TVPDIASVEV SLPSSSTGFS GGAIFNNYLF CQDPETGHLS
LVPVQVRAPE SFLGLDINLS LVPQPFQGLI TVPEKTEAPL VNVPTGPVNT HSVIRALSGQ
TRQNENRPSA ASLSNVHPAL QDVINLLKGE FSFKGYFSDG QEDVAVGEYV FSLKDLEYET
FAGVVKXXXX XXXXXXXXXX VLHCLVNNSP STLSCSSPTS SKAVKGVDLS SPLIASVWRE
KEDSLHNRLD LNGNIHISSP DSVDSWRETD TVCHHVRGET APADSDLKLE TQQPSDRQGI
TMDTSDTGLM EGGDDMAGVA DESPSEVECT SAGEAELLEA CDDEQMSPDS SEDMEDSGSL
VSEQFLTPGS KAGGLGLFLR PAWYLAIFEE QCFSPEVSEY AVSLGQHTGT PCLDVKRQEL
QQQLMIETRN LKKMRNFYLK LLQQERKHKG SANKLMLSKL KSQLEELRSK VMFLESVMKY
LEILSVEQWG LEVSLLPSLV SGSVDLHPSE DVSFLNFGNS KQKRILQAGS PQGLMAYLYS
RNAASEGYIQ QFLYTYRFLC TPEQLLQFLM NKFISAARHG PDTSGENTKI FRRTLDLLQF
WITTCTEVDF TPKSSLVATL ENFINTEVIP SDARGQVLLA ALHNLQNTSG GQNRLSPTGL
DEETDSMSVH SSREDLGRKW RISRAVELSA STPKENFFSI AAALPVPCCG TLLFSQNECS
AQHIAQQLTL LQQEMFRGCH PVHFLNSRIQ GITDNMLIPN KNVSQHTPPA EGNSVREGTA
SDSHLQQLLT YADSVTNWIS SEIVLCDSTK AQVALVTKYL WIGKHCYESR NFATAMQVLA
GLENVSVRQL PVWKHLPSKV LEILDELRAV QVFLKSDDLC LITGRHLKMK PTLPPVHVLA
MHVQQLEIGA FTLTTGAYKW SKLRSIAKVI GSRQR
//