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Database: UniProt
Entry: A0A3P8VRT1_CYNSE
LinkDB: A0A3P8VRT1_CYNSE
Original site: A0A3P8VRT1_CYNSE 
ID   A0A3P8VRT1_CYNSE        Unreviewed;      1595 AA.
AC   A0A3P8VRT1;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Kinase non-catalytic C-lobe domain containing 1 {ECO:0000313|Ensembl:ENSCSEP00000015986.1};
GN   Name=KNDC1 {ECO:0000313|Ensembl:ENSCSEP00000015986.1};
OS   Cynoglossus semilaevis (Tongue sole).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC   Cynoglossinae; Cynoglossus.
OX   NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000015986.1, ECO:0000313|Proteomes:UP000265120};
RN   [1] {ECO:0000313|Ensembl:ENSCSEP00000015986.1, ECO:0000313|Proteomes:UP000265120}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24487278;
RA   Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA   Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA   Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA   Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA   Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA   Zhao Y., Schartl M., Tang Q., Wang J.;
RT   "Whole-genome sequence of a flatfish provides insights into ZW sex
RT   chromosome evolution and adaptation to a benthic lifestyle.";
RL   Nat. Genet. 46:253-260(2014).
RN   [2] {ECO:0000313|Ensembl:ENSCSEP00000015986.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   Ensembl; ENSCSET00000016189.1; ENSCSEP00000015986.1; ENSCSEG00000010219.1.
DR   GeneTree; ENSGT00390000011408; -.
DR   Proteomes; UP000265120; Chromosome 12.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR011019; KIND_dom.
DR   InterPro; IPR029899; KNDC1.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR21560:SF0; KINASE NON-CATALYTIC C-LOBE DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR21560; VERY KIND PROTEIN; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00750; KIND; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS51377; KIND; 2.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          1..122
FT                   /note="KIND"
FT                   /evidence="ECO:0000259|PROSITE:PS51377"
FT   DOMAIN          370..535
FT                   /note="KIND"
FT                   /evidence="ECO:0000259|PROSITE:PS51377"
FT   DOMAIN          1182..1310
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          1380..1595
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          212..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          528..575
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          957..981
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..233
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        540..554
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1595 AA;  176992 MW;  1DC861BF06CFF497 CRC64;
     MEQLSDDPEG SFVPPEFDNT GSTFEGHIFS LGSTLFAALN FVIEPELEVE IGEEIQKLLE
     QMQDEKPEDR PLLQEILSLA KARLYDASSA AVCRKLSSIG RRVLSIESVS PFQDGQEGTW
     EARWQHQGPR CAFERLSSDK NNKDVCTDGS DKTNCLSRQQ VCRGWDSSLW SEDMEEDGLS
     LADEMDCRSH NSSPVRRRAQ QRLTRVKGAL NRSCSVPDSN NPPSLSTPTH GNISIPISDL
     TEIGADDHVS STSVWSNRLQ RLNRGNSCDA YTHSSTEYYE NSVDNQRSQV HQGSDETLCI
     EEESTHDVLQ GERKDSTQDL ASPCSSCQDL EMAQESPENQ SPVNHNLYFT NNHMTKSMLC
     LNEESQDEWI SLRELLSRCG RRLTVNELWA LCYTCLSSLQ TYIDFPAYLC LDTVYVGCEG
     EVLFLKPKNI GPRDEFYLAP EYQEHGIVTE KVCVYAVAAI LWATAKFSLS PTQKLAMPRK
     LKRLLLEMAK RTPIERPTII MAKKSCRDYL LGQETSAETV WNDLISRVHP PVSQPKGDED
     FNLSETHHSS SEDSEQNDSS FVPMATESRL APVPGPVPYS YPVSTRLQLP EAFTSTATHF
     VPIVLTNKGD SEKEGQNIEA VFQGDEEEFT TLNNEVALPE CPRPVQAETN LHTEEPLVNF
     SLKTLTSTSS SNNTPASSCL TVPDIASVEV SLPSSSTGFS GGAIFNNYLF CQDPETGHLS
     LVPVQVRAPE SFLGLDINLS LVPQPFQGLI TVPEKTEAPL VNVPTGPVNT HSVIRALSGQ
     TRQNENRPSA ASLSNVHPAL QDVINLLKGE FSFKGYFSDG QEDVAVGEYV FSLKDLEYET
     FAGVVKXXXX XXXXXXXXXX VLHCLVNNSP STLSCSSPTS SKAVKGVDLS SPLIASVWRE
     KEDSLHNRLD LNGNIHISSP DSVDSWRETD TVCHHVRGET APADSDLKLE TQQPSDRQGI
     TMDTSDTGLM EGGDDMAGVA DESPSEVECT SAGEAELLEA CDDEQMSPDS SEDMEDSGSL
     VSEQFLTPGS KAGGLGLFLR PAWYLAIFEE QCFSPEVSEY AVSLGQHTGT PCLDVKRQEL
     QQQLMIETRN LKKMRNFYLK LLQQERKHKG SANKLMLSKL KSQLEELRSK VMFLESVMKY
     LEILSVEQWG LEVSLLPSLV SGSVDLHPSE DVSFLNFGNS KQKRILQAGS PQGLMAYLYS
     RNAASEGYIQ QFLYTYRFLC TPEQLLQFLM NKFISAARHG PDTSGENTKI FRRTLDLLQF
     WITTCTEVDF TPKSSLVATL ENFINTEVIP SDARGQVLLA ALHNLQNTSG GQNRLSPTGL
     DEETDSMSVH SSREDLGRKW RISRAVELSA STPKENFFSI AAALPVPCCG TLLFSQNECS
     AQHIAQQLTL LQQEMFRGCH PVHFLNSRIQ GITDNMLIPN KNVSQHTPPA EGNSVREGTA
     SDSHLQQLLT YADSVTNWIS SEIVLCDSTK AQVALVTKYL WIGKHCYESR NFATAMQVLA
     GLENVSVRQL PVWKHLPSKV LEILDELRAV QVFLKSDDLC LITGRHLKMK PTLPPVHVLA
     MHVQQLEIGA FTLTTGAYKW SKLRSIAKVI GSRQR
//
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