ID A0A3P8VRU8_CYNSE Unreviewed; 422 AA.
AC A0A3P8VRU8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=5-hydroxytryptamine receptor 3A-like {ECO:0000313|Ensembl:ENSCSEP00000017024.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000017024.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000017024.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000017024.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_008327753.1; XM_008329531.2.
DR RefSeq; XP_016895919.1; XM_017040430.1.
DR AlphaFoldDB; A0A3P8VRU8; -.
DR Ensembl; ENSCSET00000017236.1; ENSCSEP00000017024.1; ENSCSEG00000010942.1.
DR GeneID; 103392803; -.
DR KEGG; csem:103392803; -.
DR GeneTree; ENSGT00920000149199; -.
DR InParanoid; A0A3P8VRU8; -.
DR OMA; TWPLVHG; -.
DR OrthoDB; 4235098at2759; -.
DR Proteomes; UP000265120; Chromosome 17.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR PANTHER; PTHR18945:SF928; 5-HYDROXYTRYPTAMINE RECEPTOR 3A-LIKE-RELATED; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..422
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018308919"
FT TRANSMEM 227..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..179
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 231..310
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
SQ SEQUENCE 422 AA; 48061 MW; 4632A58793F0F99D CRC64;
MASLTVFNHS LKNCVLWFVL TGSVLPASSC TSRRCLAEML INRNYTSQPQ YENCTHIIKV
PLVEYQTLSV DTRNLLLNSR LQATLMWTDP GLTWNTSVYH YDQVVLPVEK VWTPEIHVTN
GIRTRMHQYS NDLLLFSNGT LVHTVIIMAE VNCEVNLFNY PFAEDACPVA IQTWAVAGCG
TSLRLGNLKM IDSSHGDWET LGVSFEKQSE DQNYIWVLLR IKHFNPFITL MFPTILIVLA
DVVSFSLPLG GGERNTFKVT LVLSHTMLLT ILNEKLPGDS QCSPIIRLHF CICLVLLFLS
MLVSLVLTRV AKEGSIIFCC CPKKNATKST GNKKEDTEAK GDISVIKLNG PEEENQMLQR
VVKILQSFEN KELENEKYQN RANAIDKAFF WLYFVCSTLY FCSMLTVMRT YECTVNHFNF
WD
//
