ID A0A3P8VSK4_CYNSE Unreviewed; 1079 AA.
AC A0A3P8VSK4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=BRCA2 protein {ECO:0008006|Google:ProtNLM};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000017327.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000017327.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000017327.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 244447.ENSCSEP00000017327; -.
DR Ensembl; ENSCSET00000017541.1; ENSCSEP00000017327.1; ENSCSEG00000011108.1.
DR GeneTree; ENSGT00940000177583; -.
DR InParanoid; A0A3P8VSK4; -.
DR OMA; KAMMSDC; -.
DR Proteomes; UP000265120; Chromosome 4.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR InterPro; IPR015525; BRCA2.
DR InterPro; IPR002093; BRCA2_repeat.
DR PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR Pfam; PF00634; BRCA2; 3.
DR PROSITE; PS50138; BRCA2_REPEAT; 5.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REGION 518..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1079 AA; 117412 MW; B7028FAC01CBD79A CRC64;
MYDEFKDDIW KELGPLDPEW FQVVMTETST VEENISSVSH NTSAKQEGCF KTPYHRAAAE
SQQFSTPKVF RRSVIMSPEM EDEQTVTAEG TISSFYNLTA NITTESDAER ISESLGAHVD
PDVSWTSSLN TPPAILKFVV CLFFPQFVRR LFPSLSTQSN DSHHLQSPSG PSWIQNLPDV
IEDEVVRSTV ANVLDGTENI LSIFFPNTSS SLRKVKTDRV KRRQIXXXXX XXXSLLQTLF
HPQKGQLIRT LTNCLLPHQH FVKPLSKAQD EAISCNVSEN AQKRQTLPEN YLPPSVQPKD
EDLNMSQLCK DFAQDFSQMF DPGKQTEVTD TASENLFSSS ACLSAMKQAK RELKLENSPV
TNQNITESLA MYSGFQSAVS NVTHMATTFP TSQNGQSPQP KTEIHRATWR NVTRHSEQTL
CDSDTNMKQT TETAENINLN GVEKMQLHAD GSLTQSINMS LPKKEASSHP SYLPSGFKTA
SNNEIQIFSA QLKKAKSLFE EIEAGMTPVD SVTTKVHQSE GQGSISKGSA RKTGSNLNPL
SNDMVDMSCQ LTASQKADVT ELCTLLEEAD SQFDFTQVKS TKPEKNDSFP QNIDKELDPD
FLVGIDFDDS FSAEAEKLVE TVLDKTDSVT QAKTNCKTGI VTSQFLDGCL TQENCAVDQN
TQQKLIISDG DTFEAKGFEK TKMDTAVCIN GFQMASGKSI SISAKAIQEA DTFFEDCDIG
VSNTSLSMKP TKNMEQSPKG SFAYAEQQAE CLGNKILSYK DSNKQLAQKV AASQISGKTN
TFELPTLKNG GFQTASGKGV VVSSAALKKA RSILNECEAV EDKIFSSDSP GNGKSLAANG
KPLQKTAAHF GDITSHAEVQ RNILPASSGS TSLDCAATVN HQRNYGRVFS AASAQAITSA
DPLEKAELFF AEDPTPGCTG KKMSQNRDIS KTGGFQTASG KGVVISSAAL KKAQLLLTEC
ESDSKVLPKA DITSSAKISA TNAVLPRADQ SLNKQLSTQS CATSQKCGPG RTDRSGDTGG
GFCTASGKKV SVSAEALKKA QCHLNDMNST DDVKELLTKK GEDLPVTKET LSLWTYIKD
//
