ID A0A3P8VST6_CYNSE Unreviewed; 852 AA.
AC A0A3P8VST6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=LDL receptor related protein 8 {ECO:0000313|Ensembl:ENSCSEP00000017397.1};
GN Name=LRP8 {ECO:0000313|Ensembl:ENSCSEP00000017397.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000017397.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000017397.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000017397.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR AlphaFoldDB; A0A3P8VST6; -.
DR STRING; 244447.ENSCSEP00000017397; -.
DR Ensembl; ENSCSET00000017615.1; ENSCSEP00000017397.1; ENSCSEG00000010835.1.
DR GeneTree; ENSGT00940000154819; -.
DR InParanoid; A0A3P8VST6; -.
DR Proteomes; UP000265120; Chromosome 20.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 6.
DR Gene3D; 2.40.128.620; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 6.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270:SF66; CUB AND LDLA DOMAIN, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00057; Ldl_recept_a; 7.
DR Pfam; PF00058; Ldl_recept_b; 4.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 7.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 7.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 4.
DR PROSITE; PS50068; LDLRA_2; 7.
DR PROSITE; PS51120; LDLRB; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..852
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018270957"
FT TRANSMEM 737..759
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 347..361
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT DOMAIN 386..401
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REPEAT 490..532
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 533..576
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 577..621
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 34..46
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 41..59
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 96..111
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 115..127
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 122..140
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 134..149
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 155..167
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 162..180
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 206..218
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 213..231
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 225..240
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 245..257
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 252..270
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 264..279
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 293..311
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 852 AA; 94352 MW; 657FA80FD29FEFDE CRC64;
MAHTHTHTIT FFPLVCFSRV CVKVTRDLLV VKTCAPAEFA CLNGQCVPGR WRCDGEPECP
DGSDEAEETC SKQTCPPEKF DCGGATNKCV SLSWRCDGEK DCENGADEED CAAVCPSGEF
MCANRKCLAT VYLCDSDDDC GDGSDELKCG SPLTCGPNHL RCNSSECVPL MWSCDGDPDC
SDGSDEGPER CGGDGLTYLL NRRANCTAGE FRCDNGECVR LTWKCDGDPD CKDKSDEADC
PLLTCRPDEF QCGDGSCIHG TKQCNKVHDC PDHSDESGCV NATKCEGPLK FLCKNGECID
SSKVCDSVKD CKDRSDEPKK ECGLNECMIN NGGCSHICMD RPIGFECQCP AGYQLLDKKT
CGDIDECHYP DSCSQICINY KGDFKCECYE GYEMDPVTKT CKAEGKSPYL LFTNRHEIRR
IDLVKREYSQ VVSTQKNAVA LDLDMANNRV FWCDRFYRKI YRDAEKRKKV PLVDSSLQTP
VGLALDWLQH NLYWTDSGDK SISVASVDGT KRRVLINTDL SEPRAIALDP HHGFMYWSDW
GTRAKIEKAG MNGVDRQVLV ANNIEWPNGI TLDVANRRLY WVDSKLHHIA SVDLNGAHRR
THISSAETLG HPYALAVFED RIYWTDRDRA AVFVANRLTG QEVHMLAENL NDPHDIVVFH
QLRQDSCNLG SVANGGCEYL CLKAPQITEH SPKYTCTCPD GQALGQFCFW LKDTASLNYS
PPALSVPLHA CSPLCAFHYH GLALPLVFGL VCTGVYLVWR NWRTNSTKSM NFDNPVYRKT
TGEGEEDEIH IGRTDAMAHH AHHHPYPQGI SVGVVGAGGG TCPQFIALPL GGSMPDPGTH
WYTEQPMLST AK
//
