ID A0A3P8VTB1_CYNSE Unreviewed; 887 AA.
AC A0A3P8VTB1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Desmocollin-1-like {ECO:0000313|Ensembl:ENSCSEP00000017572.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000017572.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000017572.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000017572.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of intercellular desmosome junctions. Involved in
CC the interaction of plaque proteins and intermediate filaments mediating
CC cell-cell adhesion. {ECO:0000256|RuleBase:RU004358}.
CC -!- SUBCELLULAR LOCATION: Cell junction, desmosome
CC {ECO:0000256|ARBA:ARBA00004568}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}.
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DR RefSeq; XP_008332597.1; XM_008334375.2.
DR AlphaFoldDB; A0A3P8VTB1; -.
DR STRING; 244447.ENSCSEP00000017572; -.
DR Ensembl; ENSCSET00000017790.1; ENSCSEP00000017572.1; ENSCSEG00000011279.1.
DR GeneID; 103396334; -.
DR KEGG; csem:103396334; -.
DR CTD; 560091; -.
DR GeneTree; ENSGT01030000234624; -.
DR InParanoid; A0A3P8VTB1; -.
DR OMA; ITMRAVD; -.
DR OrthoDB; 4539697at2759; -.
DR Proteomes; UP000265120; Chromosome 20.
DR GO; GO:0030057; C:desmosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0060027; P:convergent extension involved in gastrulation; IEA:Ensembl.
DR GO; GO:0002159; P:desmosome assembly; IEA:Ensembl.
DR GO; GO:0055113; P:epiboly involved in gastrulation with mouth forming second; IEA:Ensembl.
DR GO; GO:0060047; P:heart contraction; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 4.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR014868; Cadherin_pro_dom.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR InterPro; IPR009122; Desmosomal_cadherin.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF78; CADHERIN-LIKE PROTEIN 26; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 4.
DR PRINTS; PR00205; CADHERIN.
DR PRINTS; PR01818; DESMOCADHERN.
DR SMART; SM00112; CA; 4.
DR SMART; SM01055; Cadherin_pro; 1.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..887
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017995968"
FT TRANSMEM 665..692
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 150..232
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 232..339
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 340..452
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 453..558
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 577..678
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 887 AA; 97537 MW; D55A6EBDDB87DBDA CRC64;
MANIFVFALS FMLSLLRVEP CFIPDSLYLL VPQQIQPDFE LTKVGTANCD SKTLRLTLSD
ESFEFNNGRI VAVTDVYVGA GGRTFYVRAE DGSGPQSEME VHLIHSTLQK PKPKEGLLKR
TKRRWSPPPF NILENDPGPY PKEIERIVSD SSATHDVYYT FSGPGFNEHP VGVFSLDKDS
GMLKVHQTVD REMFPNFTLT TKVFDKHTMQ PTDSPLPIQI IVDDVNDNAP EFKSALQFSV
LEHSKSGTSV GKVEATDRDQ EGTTHVKIKY SLLTGSDKFS INPVTGVITT LVGNLDREVK
DKQLVTVEIK DMNGAPIGLS NTGTATITIG DINDNPPTFT KASYNANVKE NEQDKLILHI
PVEDKDLINT PNWKSKFIIT KGNENGIFRI DTDPKTNEGL LYVVKPLNFE KNKNVKLEVM
ARNEADLSNT DAKWQTVPVD ISVTDIDEGP EFSAPTVRFT VKENTPNGTL IGSYTATDPE
TKSSDGIKYY KSTDPAAWIN VDKNTGELRV ANTIDKESHF VQNGIYNITM KAVDVTSKTG
TGTVIIQVED VNDNVPTLPT GERVICEKDG ELGSVYVVAE DKDESPFSSP FSFNLPKDND
GKWTMATYNA TTGILKQIKE LPRGIYQVPV DVTDLQGFGK TQTVTVRICQ CRNGICLAKD
RSVTLGGLAV LAMLLPLLLL LLLCLLLAFI CVTKREKREI EDTGDSGGIL LQSNTEGKGD
EVDASLIIVP TSGVDIDLTK GSVKDLNTGY IKGSMGTMGG HNIHESWRYK SNEIDSGQFD
QNGKLGGHYG HLVNSGVSAD SRYVQDASFL HNWQTNGRYL HKKLDYFVSE EDGRYADDII
HSYGFEGAGS AAGSVGCCSE FGDNENLDFL NALGPKFKTL ADVCKKT
//
