ID   A0A3P8VTC3_CYNSE        Unreviewed;       799 AA.
AC   A0A3P8VTC3;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Myotubularin related protein 11 {ECO:0000313|Ensembl:ENSCSEP00000018458.1};
OS   Cynoglossus semilaevis (Tongue sole).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC   Cynoglossinae; Cynoglossus.
OX   NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000018458.1, ECO:0000313|Proteomes:UP000265120};
RN   [1] {ECO:0000313|Ensembl:ENSCSEP00000018458.1, ECO:0000313|Proteomes:UP000265120}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24487278;
RA   Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA   Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA   Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA   Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA   Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA   Zhao Y., Schartl M., Tang Q., Wang J.;
RT   "Whole-genome sequence of a flatfish provides insights into ZW sex
RT   chromosome evolution and adaptation to a benthic lifestyle.";
RL   Nat. Genet. 46:253-260(2014).
RN   [2] {ECO:0000313|Ensembl:ENSCSEP00000018458.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR   AlphaFoldDB; A0A3P8VTC3; -.
DR   STRING; 244447.ENSCSEP00000018458; -.
DR   Ensembl; ENSCSET00000018687.1; ENSCSEP00000018458.1; ENSCSEG00000011837.1.
DR   GeneTree; ENSGT00940000160276; -.
DR   InParanoid; A0A3P8VTC3; -.
DR   OMA; GWQRSQD; -.
DR   Proteomes; UP000265120; Chromosome 13.
DR   InterPro; IPR022587; MTMR12-like_C.
DR   InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR   InterPro; IPR030564; Myotubularin_fam.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR   PANTHER; PTHR10807:SF51; MYOTUBULARIN-RELATED PROTEIN 11; 1.
DR   Pfam; PF12578; 3-PAP; 1.
DR   Pfam; PF06602; Myotub-related; 2.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT   DOMAIN          204..647
FT                   /note="Myotubularin phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS51339"
FT   REGION          685..799
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        692..722
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        737..772
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   799 AA;  90237 MW;  0EE0090A9A79625F CRC64;
     MLTGSKTTFK VRQMLPDIKE RMLSQSGVNS RSRDVFGLHC LPGECILQRA VMVRKKLTAR
     EGRGWLSGTL FCTHFRVAFV PQESIKPDDN ADPVLLGDHD VALASIDKVV VVGPNRTKLM
     TPNSSLKFTP EELVLYCRDM QVICFLFDRL TPDAQVIEMT YTIVKTYQPL KPGSVLSFQN
     AALGSIEMKQ FLSNRRRDTK MNWFETTSDW EQELARCAAT GWRVSSVNDR FEMSTSLPRF
     VVVPQKVLDT ELKKSFAHFN DGRIPRWCWQ HPQGSVLLRM ASFQNNIYHE KDDIRNLEMI
     LFGCHSSLYI SASLSVTDDK WLSTLESTHW LDYTRSCLRK ASEVACLLRG SHLTVALQEA
     EDRDMSCVVS SLVQVMCDPY CRTQHGFQSL VQKDWVMAGH RFYSRMNYHR DNDKEEAPVF
     LLFLHCVWQL WSQYPSRFQL TEDFLLALHD SIHLPLFSSF LANCQRERCK RSQNQGQSYT
     PVKGWRDELP QDPSADLCDP PLPPVWDWAL QYSKHRQESF TQPVATTTVH QPLLNGNLNI
     KKDQHKVGLL TETIPGSVFL FSRGTFSCPP NLLPWRTSSS GVYKKSHRRA LSSEGMPGLE
     KLLKAWALAD FPQSLSCNSE PRRPCDPSEP LLPLLLGPCM GLWRECFLRG ALHAQAFSHP
     ISANHPHPVE RLAKEVRHLK HQLAKFASGT DTKPPVKSSE QRPTDTNSNQ NANNSTFLFS
     ASRPHGTCAL RPVPAPTATH PQTSRGCPPA TAPTSRPSDR DSSVSKHTFL FGRSSSAEAC
     PGQRHYPTKV HKGSGSAAS
//