ID   A0A3P8VTH2_CYNSE        Unreviewed;       295 AA.
AC   A0A3P8VTH2;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=Myeloid-associated differentiation marker-like protein 2 {ECO:0000256|ARBA:ARBA00040733};
GN   Name=MYADML2 {ECO:0000313|Ensembl:ENSCSEP00000017632.1};
OS   Cynoglossus semilaevis (Tongue sole).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC   Cynoglossinae; Cynoglossus.
OX   NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000017632.1, ECO:0000313|Proteomes:UP000265120};
RN   [1] {ECO:0000313|Ensembl:ENSCSEP00000017632.1, ECO:0000313|Proteomes:UP000265120}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24487278;
RA   Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA   Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA   Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA   Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA   Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA   Zhao Y., Schartl M., Tang Q., Wang J.;
RT   "Whole-genome sequence of a flatfish provides insights into ZW sex
RT   chromosome evolution and adaptation to a benthic lifestyle.";
RL   Nat. Genet. 46:253-260(2014).
RN   [2] {ECO:0000313|Ensembl:ENSCSEP00000017632.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the MAL family. {ECO:0000256|ARBA:ARBA00034721}.
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DR   AlphaFoldDB; A0A3P8VTH2; -.
DR   STRING; 244447.ENSCSEP00000017632; -.
DR   Ensembl; ENSCSET00000017851.1; ENSCSEP00000017632.1; ENSCSEG00000011316.1.
DR   GeneTree; ENSGT00950000182933; -.
DR   InParanoid; A0A3P8VTH2; -.
DR   OMA; GTFCMFV; -.
DR   Proteomes; UP000265120; Chromosome 17.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008253; Marvel.
DR   InterPro; IPR047123; MYADM-like.
DR   PANTHER; PTHR17068; MYELOID-ASSOCIATED DIFFERENTIATION MARKER MYADM FAMILY MEMBER; 1.
DR   PANTHER; PTHR17068:SF5; MYELOID-ASSOCIATED DIFFERENTIATION MARKER-LIKE PROTEIN 2; 1.
DR   Pfam; PF01284; MARVEL; 2.
DR   PROSITE; PS51225; MARVEL; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU00581}; Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU00581};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        46..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        82..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        119..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        150..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        187..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        224..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        272..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          13..148
FT                   /note="MARVEL"
FT                   /evidence="ECO:0000259|PROSITE:PS51225"
FT   DOMAIN          153..295
FT                   /note="MARVEL"
FT                   /evidence="ECO:0000259|PROSITE:PS51225"
SQ   SEQUENCE   295 AA;  32724 MW;  485CC00877B824EE CRC64;
     MDPHGGHYLN KDAVLSPLGA VRISQLLLGC TIMALVSHSA GYSATYGHFC MFVWCFCFAV
     TLVVFTLDIT RLHTCMPISW DNFTVAFAML ATLMYITASV VYPVYFLDSE CSGDSCEVQI
     YRIAVTVCSS ICCFPYGAEV FLTRAKPGAV VGYMATVSGL LKVVQAFVAC IIFGALAVDT
     DYNKYIATQY CVVVFSLCFS VTVIVIVLTV SGRTSSLRFP FDRFVVVYTF LAVILYLSTA
     LVWPIFSFDK KYGTTSRPYY CPRGDCPWDS KLVVAVFTCV NVVLYFIDLV YSQRI
//