ID A0A3P8VTU1_CYNSE Unreviewed; 442 AA.
AC A0A3P8VTU1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=LDL receptor related protein 8 {ECO:0000313|Ensembl:ENSCSEP00000017729.1};
GN Name=LRP8 {ECO:0000313|Ensembl:ENSCSEP00000017729.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000017729.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000017729.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000017729.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8VTU1; -.
DR Ensembl; ENSCSET00000017947.1; ENSCSEP00000017729.1; ENSCSEG00000010835.1.
DR GeneTree; ENSGT00940000154819; -.
DR Proteomes; UP000265120; Chromosome 20.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR PANTHER; PTHR46513:SF36; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF00058; Ldl_recept_b; 4.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS51120; LDLRB; 3.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 363..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 62..104
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 105..148
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 149..193
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 396..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..425
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 442 AA; 48928 MW; 0338DA59FAC16876 CRC64;
MLCTCVALDL DMANNRVFWC DRFYRKIYSA FIHDASDPSQ QVPLVDSSLQ TPVGLALDWL
QHNLYWTDSG DKSISVASVD GTKRRVLINT DLSEPRAIAL DPHHGFMYWS DWGTRAKIEK
AGMNGVDRQV LVANNIEWPN GITLDVANRR LYWVDSKLHH IASVDLNGAH RRTHISSAET
LGHPYALAVF EDRIYWTDRD RAAVFVANRL TGQEVHMLAE NLNDPHDIVV FHQLRQPRGQ
DSCNLGSVAN GGCEYLCLKA PQITEHSPKY TCTCPDGQGD AVLHLTTAAS STEELATSLS
ALRTASSNES KESDYRSTAS AVVVSTTPAG DSSVSQHCEC LFLAISLCVV KIIIFLSFAR
IPIVATVVFG LVCTGVYLVW RNWRTNSTKS MNFDNPVYRK TTGEGEEDEI HIGRTDADSA
DDNHLRPAGV SDSFDSFSFT AP
//
