ID A0A3P8VUX9_CYNSE Unreviewed; 551 AA.
AC A0A3P8VUX9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Transmembrane protein 145 {ECO:0000313|Ensembl:ENSCSEP00000018124.1};
GN Name=TMEM145 {ECO:0000313|Ensembl:ENSCSEP00000018124.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000018124.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000018124.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000018124.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_008322199.1; XM_008323977.2.
DR AlphaFoldDB; A0A3P8VUX9; -.
DR STRING; 244447.ENSCSEP00000018124; -.
DR Ensembl; ENSCSET00000018348.1; ENSCSEP00000018124.1; ENSCSEG00000011635.1.
DR GeneID; 103388804; -.
DR KEGG; csem:103388804; -.
DR CTD; 284339; -.
DR GeneTree; ENSGT00940000153981; -.
DR InParanoid; A0A3P8VUX9; -.
DR OMA; WFLCHPL; -.
DR OrthoDB; 2951264at2759; -.
DR Proteomes; UP000265120; Chromosome 13.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:InterPro.
DR InterPro; IPR047831; GPR180/TMEM145.
DR InterPro; IPR019336; GPR180/TMEM145_TM.
DR PANTHER; PTHR23252; INTIMAL THICKNESS RECEPTOR-RELATED; 1.
DR PANTHER; PTHR23252:SF24; TRANSMEMBRANE PROTEIN 145; 1.
DR Pfam; PF10192; GpcrRhopsn4; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..551
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017923957"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 328..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 155..408
FT /note="GPR180/TMEM145 transmembrane"
FT /evidence="ECO:0000259|Pfam:PF10192"
FT REGION 501..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..529
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 551 AA; 62487 MW; 300269F2D818CA71 CRC64;
MDSGVWGKIL WLVTLCSLLY VHSVHGKYVK GVVDTKEDWV FLTRFCFLTD YGRLDFRFRY
PKSRCCQNIL LYFDDSSQWP AVYKRPEKNC YQKEAVLRPE NNQVINLTTR YTWSGCEVEG
DDNGEVLSCV GGRSFRSVRE RWWYIALSKC GGDGLQLEYE MKLTNGQSFW TQHFSADEFG
ILETDITFLV IFSMVFLLSC YFAYNLKGRQ LLHTTYKMFM IAAGVEVLSL LFHCIYWGLY
AQDGVGNGSL KILGKLLFSV SFLVFLLMLI LLGKGFTVTR ARISHSGSVK LSIYMTVYTV
TYVILFIYEA EFFDPGEVLY AYDSPAGYGL MGLQLLAYVW FCYAVLVSMK HYPEKQPFYI
PFFTAYTLWF FAVPIMALIA NYGIPRWARE KIVNGIQLGI YLYAHIVFLI ITRPSAANKN
FPYHVRTSQI GILLSSPKCG EGAESFPHHA YGNSSFVGDS QPNFTELFSI QSDAVKTVAE
TVACKEPEVQ RNSEQKIITT ATDTTSILPP PPIPPRPATR SPPLPPRLPS FTEYFSMQSD
SSGGAGYGTK A
//
