ID A0A3P8VV71_CYNSE Unreviewed; 2163 AA.
AC A0A3P8VV71;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|RuleBase:RU364134};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000018227.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000018227.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000018227.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
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DR RefSeq; XP_008331054.1; XM_008332832.2.
DR STRING; 244447.ENSCSEP00000018227; -.
DR Ensembl; ENSCSET00000018452.1; ENSCSEP00000018227.1; ENSCSEG00000011668.1.
DR GeneID; 103395204; -.
DR KEGG; csem:103395204; -.
DR CTD; 100004024; -.
DR GeneTree; ENSGT00390000013680; -.
DR InParanoid; A0A3P8VV71; -.
DR OrthoDB; 9289at2759; -.
DR Proteomes; UP000265120; Chromosome 19.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF4; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 1375..1720
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1756..2152
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 328..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 739..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 802..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 982..1059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1479..1546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1564..1612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2009..2044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..481
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..548
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..583
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..613
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 739..763
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 982..1009
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1013..1027
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1028..1059
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1564..1604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2029..2043
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2163 AA; 237404 MW; 6B5DA088D9D230EC CRC64;
MSSCFVPNGA SLEDCHSNLF CLADLTGIKW KRFVWQGPTS APILFPVTEE DPILCSFSRC
LKADVLSVWR RSQRQGRREL WLFWWGDDPN FADLIHHELA VEDDGLWENG LSYECRTLLF
KAIHNLLERC LMNRSFVRIG KWFVKPYEKD EKPINKSEHL SCAFTFFLHG DSNVCTSVEI
NQHQPVYHLT EEHLTLAQQA SNPFQVILSP FGLNGTLTGQ SFKMSDPPTQ KLIEEWNQFY
PIGPSAKQGL SEDKTEDMHW EDDSLASVEV LVGGVRMVYP ACLVLVPQSD IPVVAPVGSS
HCTAIYSGGH QVPASQREPA ISLVTLTPPT SPEEVQTGSD NTKVDSNSSK KWVNMPPSSD
GFSMDRTSHH GGKIPRRLST QVVERVWQEC NINRAQNKRK YSAATNGTCE EELTEKVGTW
NFVEPSQRSH CNCSRHKSVK QRTGSTPGQA QLSGQASQPP TKHKAGGEKL EKGEKQQKRP
QTPFHHRSLT NDEASLDSET NVGQRLAMRN QDGGRLPSIC SADVSAIQKT PQLHSGAVNS
GPSDQANSPQ PPSLSPHPCE RSEESGEGMK NPSTPNSQHF YQQPPDPCLV GVKGGSEELS
STESISQHFN SHHPHPGVSA YSDSPEPVVY IGAAVNQEED NSHTPWRLFN LPRRKEAEVP
TPLLPGDKLK DEASLSQENL VSVTEIMSTS KWPLKVSEEL IQMYRARRNQ YLSAAITDGD
HEPEADPYAF EEGDVKFTFS KKDKAGGERD PGKKHKGEDG GSCPSDDAQR AAAHNHTVST
SLIHEIDLAV SINDLDNLFN SDEDELAPGS RRPVNGTDEK FGNKDPKPST LDPVSCISSA
DLHQMFPTPP SLEQHIMGYS PMNMCSKDYG SMESNAGMTT LDGTSSLGNH FKIEVEESFC
SPKPSEIKDY SFVYKPELCQ AFVGCSMFAP LKTLPSQCLP PIKMPEEGIY RPSWTMGRDM
TFLSKDSTIT SVANVMDQDY NQTYTPQTHT PFMSNSAPPS NSGTGILPSP ATPRFSAPTP
RTPRTPRTPR GPSSVQGSLK YENSDLYSPA STPSTCRPLN SVEPATVPSI PEAHSLYVTL
ILSESVMNLF KDCNFDSCCI CVCNMNIKGA DVGVYLSDPV SEAQEPCSCG FSAVVNRRYG
NGSGLFLEDE LDIIGRGSDV SREAEKRFEE LRLSSLEKSG VGRGDRVPDE LIVLVQDQCT
NPFSPISILE HDLVTRGTGG VSVPPCVRVE EKDYCSDCYM ALEHGRQFMD NMSGGKVDEA
LVKSSCLHHW GKQNAVDVSA LCSQDVLRAL MSLQPVLQDA IQKKRTVRSW GVQGPLTWQQ
FHKMAGRGSY GTDESPEPLP IPTFLVGYEY DFVVLSPFCL PYWEKLLLDP FGSQRDIGYL
VICPDNEALL SGAKSFFRDL TAVYESCRLG QHRPISKGYP DGIVLVGGSG AKSLMDQPVS
DWFLKAASGN SDAFAKLKLY AQVCRHNLAP YLASQPLDSS LLTQPNPSPS SSQSSSTQLS
SSTSSSVGQQ SSTTAAGPTV PNSSSNAGSG NSSASTNNLV TTSGQSGPAL LSAKANCFPS
FGSMSSQGQG VGPQSGQLGQ QAGTQNAGSS GDNSSSQAQG PSEPPESTLE REKVGLPTDG
ESHAITYPPA IVVYIIDPFS YEETENGTGP VPAHSSVWTL GLLRCYLEML QFLPAHIRNS
VYVQIVPCQY LLQPVRREER HIYAQHLKSL AFSVFAQCRR PLPISTNVKS LTGFGPGLAI
DTALKSPERP ECLRLYTPPF ILAPVKDKQT ELGETFGEAS QKYNVLFVGY CLSHDQRWLL
ATCTDLYGEL LETCIINVDV PNRARRKKGS VRRFGLQKLW DWCLGLVQMT SVPWRVVIGR
LGRIGHGELK DWSILLSRRN LQSLSRRLKD MCRMCGISAS DTPSILSVCL VAMEPQGSFI
IMPDSVSTGS VFGRSTTLTM QTSQLSTPQD TSCTHILVFP TSAFVQVASS SYTNIDTNID
ILNATTDGSD IFDLLDQENE LVDPDIINIS PNTSPVHSPG SHYHHGGDGS KGQSTDRMES
HEEVPNLLQQ PLALGYFVST ARAGPLPDWF WSACPQAQNQ CPLFLKASLH LHVSSVQSDE
LLHSKHSHPL DSNQTSDVLR YVLEQYNALS WLTCDPATQD RRSCLPIHFV VLNQMYNFIM
NML
//
