ID A0A3P8VWA3_CYNSE Unreviewed; 1287 AA.
AC A0A3P8VWA3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Partitioning defective 3 homolog {ECO:0000313|Ensembl:ENSCSEP00000018599.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000018599.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000018599.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000018599.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004308}.
CC -!- SIMILARITY: Belongs to the PAR3 family.
CC {ECO:0000256|ARBA:ARBA00005358}.
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DR Ensembl; ENSCSET00000018830.1; ENSCSEP00000018599.1; ENSCSEG00000011895.1.
DR GeneTree; ENSGT00950000183214; -.
DR Proteomes; UP000265120; Chromosome 3.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 3.
DR Gene3D; 2.30.42.10; -; 3.
DR InterPro; IPR021922; Par3/HAL_N.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR16484:SF18; PARTITIONING DEFECTIVE 3 HOMOLOG; 1.
DR PANTHER; PTHR16484; PARTITIONING DEFECTIVE 3 RELATED; 1.
DR Pfam; PF12053; Par3_HAL_N_term; 1.
DR Pfam; PF00595; PDZ; 3.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR PROSITE; PS50106; PDZ; 3.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022427};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 254..329
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 436..510
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 554..629
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 79..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 870..1001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1027..1099
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1126..1168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1212..1287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 894..909
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..1001
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1081..1099
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1140..1168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1212..1227
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1246..1260
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1287 AA; 142958 MW; 9A0A6146646CB84F CRC64;
MKVTVCFGKT RVVVPCGDGN IKVHSLIEKA AMRYKKAIAK DLNYWVQVHR LEHGDGGILD
LDDMLRDVVD DKDRLVAVYE EQDPHNGGDG TSASSTGTQS PEPFVGDLSS VSSFQPYQSS
SEIEVTPSTL RSNMPLHVRP SSDPSLAAEV PVGPEQPSRM NPVRWSTTAG FHKYNHKPNT
SRAHAYRSLP RDAGGWASQF QREMLRSSLS ANHPMVDQWL DRQEQVNAGI ERIEPVGGAD
SSVEKPPVLS LDMLKPVEVS NEGGPLGIHI VPFSSQDVRT QGLLVKRLEQ GGKAETERLF
QENDCIVKIN QGDIRNLRFE QAQNIFRQAM RSRVILFHVV PAVMKRQYEL LTGHSDHSLH
QTNRVFFSQK PGDRSSLVGG PASRLGPTPE PNRRYTTLSH SMVSRTASAP SPSLQRRIST
NPSNSSYLKN KGRQFNIQLK KGPEGLGFSI TSRDVPIGGT APIYVKNILP RGAAIQDGRL
KAGDRLLEVS GVDLGGKTQE EVVALLRATP MGGMVNLLVT RQEDPLLPRE VVSQQEEDDL
VLTPDGTREF MTYEIPLNDS GSAGLGVSVK GNRSKENHAD LGIFVKSIIN GGAASKDGRL
LVNDQLIAVN GESLLGMTNQ EAMETLRKSM SVEGNKRGMI QLIVARRFPK NCEEVPGSPT
ALEQQLNSLM DGHERRISHS LYDPVEGLDN IASPRTNVVR RIGSYQLSPT VNMPQDDIVM
IEDDRPPLLP ANLSDQSSSS SHDDMGFVGE NPVTWIHDSL SPDVDPDGTF QREGFGRQSM
SEKRTKQYSN AAELDIVKSR KSKSMDLGEF SVGPSLGLKK SSSLESLQTA VAEAALKSEI
NVNRQSSRIV RGRGCNESFR AAIDKSYEKP GVTLTEDENS METLDEDTEG SSRSGRESMS
TSGDLIVGTG LNGNLSKDDR VRDWEKIGGK EKKKPERDKE EKDKEKIKAK KGVLKGLGEM
FRFGKQKKDE RPGERMERKG SSKSKTEEMQ ASEDDTHRMR LEQERIQAKM RELREKQAKE
REYAEIQDVV SRTFSSDEEH TYAGIGSLDS SVDKAVYAQV NKLRNGRPPA PDSPMTPSNH
DRIQRLRHEF QHAKQDDDLE DHRHTYSFDQ SWVSTQSGRL SVTVDSQAQE QRLEDRDSFQ
QAQRQYSSLP RPPRKNANTA SQDSWDNVHA PTEKFQKSKE NSRYSVAQGS RNGYLATSSF
NARVLLETQE LLRQEQRRRE QEANKARPPE EPSSGSSYDQ NQGPAAAPVL PPPQSKGPYR
QDVPPSPSQL AKLSRHQGSE KGRLFYS
//
