ID A0A3P8VWC2_CYNSE Unreviewed; 1422 AA.
AC A0A3P8VWC2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Calmodulin regulated spectrin associated protein family member 3 {ECO:0000313|Ensembl:ENSCSEP00000018637.1};
GN Name=CAMSAP3 {ECO:0000313|Ensembl:ENSCSEP00000018637.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000018637.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000018637.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000018637.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- DOMAIN: The CKK domain binds microtubules. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
CC -!- SIMILARITY: Belongs to the CAMSAP1 family. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_008327832.1; XM_008329610.2.
DR Ensembl; ENSCSET00000018868.1; ENSCSEP00000018637.1; ENSCSEG00000011937.1.
DR GeneID; 103392860; -.
DR CTD; 57662; -.
DR GeneTree; ENSGT00950000182975; -.
DR InParanoid; A0A3P8VWC2; -.
DR OrthoDB; 2918432at2759; -.
DR Proteomes; UP000265120; Chromosome 17.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-UniRule.
DR GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0030507; F:spectrin binding; IEA:InterPro.
DR GO; GO:0031175; P:neuron projection development; IEA:InterPro.
DR Gene3D; 3.10.20.360; CKK domain; 1.
DR InterPro; IPR032940; CAMSAP.
DR InterPro; IPR022613; CAMSAP-like_CH_dom.
DR InterPro; IPR031372; CAMSAP_CC1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR038209; CKK_dom_sf.
DR InterPro; IPR014797; CKK_domain.
DR InterPro; IPR011033; PRC_barrel-like_sf.
DR PANTHER; PTHR21595:SF2; CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 3; 1.
DR PANTHER; PTHR21595; UNCHARACTERIZED; 1.
DR Pfam; PF17095; CAMSAP_CC1; 1.
DR Pfam; PF11971; CAMSAP_CH; 1.
DR Pfam; PF08683; CAMSAP_CKK; 1.
DR SMART; SM01051; CAMSAP_CKK; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50346; PRC-barrel domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS51508; CKK; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|PROSITE-
KW ProRule:PRU00841}; Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 200..314
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1284..1420
FT /note="CKK"
FT /evidence="ECO:0000259|PROSITE:PS51508"
FT REGION 419..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 683..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 799..973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1097..1165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1234..1281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..582
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..697
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..712
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 713..739
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..885
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 920..973
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1097..1120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1265..1279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1422 AA; 157652 MW; 8C060680F680482C CRC64;
MVDSPTMRKS FVVPEIKPLD LYDSNRAKIC ASVGWLLAKS YGSAENVPGE LSDPFYCDQY
EQEHLKPPVM RLLQSSELYC RTYSLLLGET GTDKQPKDNV ALLELLTEKG MFYKDETQVT
DADLRHKPIK MNAHLAVIDA LMAVGGMETV TVVKKCASAE LLGRATKWED ALLHWINVLN
QKLRELTEDS QEDSPQATET QPLQPTLRYR KDNIQSKQKP VFPVVNEVKD LSSGSAVAAV
IHYYCPGLLR LEDVCMKDSM SVPDSLYNLQ FIREFCDSCL KCCCHLTLED MLYVPKELQC
NFLSFLAELL SCFEVQKPDF VQPLNSLVDG ATPEKLSGLR SSSTSPSIFK KPFLPISSPA
SGSLTQSTSM SHIEGVGKTW SKKSLSRPLS AVSFSIPFGL DSDVDIVMGN PVITRSVSSD
QLNPAAQSSI RTPYTPPEDI SHVLKKPLGP AGPQRSSWTN QPTSSVPRLV EQNGLVGSEP
GELPTIEEAL QIIHNEGKLE PRLHPDGAPD GFYLHSPDDP ASLRHTVNLA AISSSAPSCS
AMTHRPLDSK EPTRTRNTSE CSRDDDSVLR DGSVDSDASE DMPRTRSTPA TPAASEFDSG
VKLTSFAERK RKQIAGSPKA TESPQMTSWA KKSEDSDGKG SELNNEVSEL GARLEEKRKA
IEAQKKRIEA IFAKHRQRLG KSAFLQLKKE QDEGEGEGSN GRVSTSGTEE ELANLTLEER
LARMEEDNQQ VQDEQHPIVK NEGNMKEELS KFFNHSQDKA GTQWEKDAVK PDKMVAPLGD
YNNAVSKLTA ALSSLQSDMQ RLTEQQNQLI IKKNPSPNNK SWVIPASPRT STPAPSRMHR
ESYRSLNSAS SSPSPSRRIT NHTTPTKSPQ VQRRTQSVPP KSPKHHQSSR TLDSKPQALS
RVLNPPQNVD RIPHLRRVVP RQSQIQTSSS FSIGDSGSLD DLHSAGSTPI ATPTLTPVQT
PTPRSTVDDS LSEVGFNDDQ SIFSMDLEAG SLDGHAARKE GGVGGGYSSG APSECSFESD
VPTGMVNGKR SSLIEIPLSA LQDGEAEEHL PDAFRTDSVN DQTESELKGG VGFFFKDDKE
RPEDEMAQRK AALLEKQQKR AEEMKRRKLE QEKEKESNKP QWMTIEGWGT KSEDRPQTPG
TPPAAKTTPV EGTPQRRGEF TRQEYERRQQ LKIMEDLDKV LRQKPTTVRG VKKQRPKTVF
RDDSMLSQSP AKGFMGTRLN KVYSHSSMNL SSMANDLSVR KSPSRSHSPS RHRSPGRSIA
LNGERDWENG STISSPASIP EYTGPKLYKE PSFKSNKFII HNAISRCCLA GKVNEPQKNK
IVEDMEKSTA NHFLILFRDA SCQFRAVYTM NPETEEMERL TGIGPRVVMP EMVESIYKYS
SDRKQFTVIP SKTMSMSVDA FTIPGHFWQK RPGTPKKLAT PK
//