ID A0A3P8VYZ9_CYNSE Unreviewed; 788 AA.
AC A0A3P8VYZ9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=TAFH domain-containing protein {ECO:0000259|PROSITE:PS51119};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000017625.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000017625.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000017625.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TAF4 family.
CC {ECO:0000256|ARBA:ARBA00006178}.
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DR AlphaFoldDB; A0A3P8VYZ9; -.
DR STRING; 244447.ENSCSEP00000017625; -.
DR Ensembl; ENSCSET00000017844.1; ENSCSEP00000017625.1; ENSCSEG00000011298.1.
DR GeneTree; ENSGT00390000011620; -.
DR InParanoid; A0A3P8VYZ9; -.
DR OMA; HQEMNSK; -.
DR Proteomes; UP000265120; Chromosome 5.
DR GO; GO:0005669; C:transcription factor TFIID complex; IEA:InterPro.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0006352; P:DNA-templated transcription initiation; IEA:InterPro.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:UniProt.
DR CDD; cd08045; TAF4; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 1.20.120.1110; TAFH/NHR1 domain; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR045144; TAF4.
DR InterPro; IPR007900; TAF4_C.
DR InterPro; IPR037249; TAFH/NHR1_dom_sf.
DR InterPro; IPR003894; TAFH_NHR1.
DR PANTHER; PTHR15138:SF22; TAFH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR15138; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4; 1.
DR Pfam; PF05236; TAF4; 1.
DR Pfam; PF07531; TAFH; 1.
DR SMART; SM00549; TAFH; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF158553; TAFH domain-like; 1.
DR PROSITE; PS51119; TAFH; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 373..470
FT /note="TAFH"
FT /evidence="ECO:0000259|PROSITE:PS51119"
FT REGION 46..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..690
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..753
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 788 AA; 83674 MW; AABB5C32752C2E9C CRC64;
MTSQPFPQCL VTRRRTMAGA SDPLEDMFFS EVDEKAVSDL VGSLESQLAG QSNQAGKTDE
NGGAGSVAPA NHLLGKTLPA PVGTTTLEQQ QGRGNKPEMR QEIKCKEVCP DKSTTPPSLG
CTPSFGEPST TSAPSVNAAG SGAQSHGASV TTLTAPGVST LASPAASIST TSSRGSKVSP
SSGTPTISLQ RLPSHIVASI TQNGNGASVT ALVQQGAAAE PSSSPQETNS KPVSETGASK
TDDCQSKIVM SSQSGSPPSC TTTTVCVTAP VTTTVCGHVT SVATTISLVR PAAPSPTPAV
ATSAQSQPRP GLTAPQRIVA PQLIVRPPQQ QTTIQLPPGF TIPPGMVLVR TELGQLVMVP
QQALAQVQAQ AQNKNVKKCK NFLATLIKLA SHNSPSPETS KNVKALVQDL LVSGTVLTWT
QYCLNEFFSY LKRGFLPALR LSLLNSQQSL IQPPQQGVKP APGGVPPAIV TGPGVRIRHP
NSVSTTTGVR MPVVITQSVR AQGTIGKGAV IQAGRGAMGM AVQISGNQKN KLNDPGGGSF
RDDDDINDVA SMAGVNLNEE SARILATNSE LVGTQIRSCK DEAFLHPGLL HRRILETAKK
FGVTDVPMEA VTFISHATQS RLRTVVEKVS TIAQHRLDSC KDDEYYEQNA DVRSQLRFFE
QLERMEKQRK DDRSRQEDPE QARLKQKAKE MQQQELAQMR QRDANLTALA AIGPRKKRKV
DSPGATPSGT EVPGSAAGSP ASSSVPSTSS RQYTRQRITR VNLRDLIFYM EQERETTHSL
LLYRALLK
//
