ID A0A3P8W0F5_CYNSE Unreviewed; 604 AA.
AC A0A3P8W0F5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Protein phosphatase 1G {ECO:0000256|ARBA:ARBA00040767};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000020069.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000020069.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000020069.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBUNIT: Interacts with NOL3; may dephosphorylate NOL3.
CC {ECO:0000256|ARBA:ARBA00038798}.
CC -!- SIMILARITY: Belongs to the PP2C family.
CC {ECO:0000256|RuleBase:RU003465}.
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DR STRING; 244447.ENSCSEP00000020060; -.
DR Ensembl; ENSCSET00000020307.1; ENSCSEP00000020060.1; ENSCSEG00000012809.1.
DR Ensembl; ENSCSET00000020316.1; ENSCSEP00000020069.1; ENSCSEG00000012809.1.
DR GeneTree; ENSGT00940000158427; -.
DR OMA; RYGQNCI; -.
DR Proteomes; UP000265120; Chromosome 5.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004722; F:protein serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0007417; P:central nervous system development; IEA:Ensembl.
DR CDD; cd00143; PP2Cc; 2.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 2.
DR InterPro; IPR015655; PP2C.
DR InterPro; IPR000222; PP2C_BS.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR PANTHER; PTHR13832:SF876; PROTEIN PHOSPHATASE 1G; 1.
DR PANTHER; PTHR13832; PROTEIN PHOSPHATASE 2C; 1.
DR Pfam; PF00481; PP2C; 2.
DR SMART; SM00332; PP2Cc; 1.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR PROSITE; PS01032; PPM_1; 1.
DR PROSITE; PS51746; PPM_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003465};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912,
KW ECO:0000256|RuleBase:RU003465};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 23..523
FT /note="PPM-type phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51746"
FT REGION 163..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..334
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..553
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 604 AA; 65345 MW; BEC452ACA9891DF3 CRC64;
MGAYLSQPNT TKTSSDGGNG NLSYGFSAMQ GWRVSMEDAH NCIPEFDEET AMFAVYDGHG
GEEVALYCSK YLPDIIKEQK TYKDGKMQKA LEDAFLAIDG KLITEDVIKE LVQIAGRPTK
ELPTEKVAEE DDLDTEEAAL LHEEATMSIE ELLVRYGNAV KHPSANSSAA KKSSCSQPDS
SEDKGEEGKE QKKESVNGEL EEESNGKLKK GEGASCGSKL RTCRKSGGGG EGSGSADCGG
SGSSNGEDKA GKAEGDAGPS CSSLSSKSKA GDSKSKFFDD SEESEEGEEE EGSDEEDVSE
EDGDSSELDE EEDTEEGEED SEDDEEEEEE MCLPGMDGKE EPGSDSGTTA VVALIRGKQL
IVANAGDSRC VVSEHGKAVD MSYDHKPEDE LELARIKNAG GKVTMDGRVN GGLNLSRAIG
DHFYKRNKAL PPEEQMISAM PDIKILTLNE EHDFMVLACD GIWNVLSSQE VVDFVSERIK
PDQSGNSRPL SSIVEELVDH CLAPDTSGDG TGCDNMTCII ITFSPHSCPT QKDNSKRKHS
EAEGSEPGEN GNDSKRAKSX XXXXXXXXXX XDDSRFTRDA FCLKMKLPYL TNGPLRDREN
YYFK
//
