ID A0A3P8W0Y7_CYNSE Unreviewed; 887 AA.
AC A0A3P8W0Y7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Calsyntenin 2 {ECO:0000313|Ensembl:ENSCSEP00000019266.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000019266.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000019266.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000019266.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004614}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004614}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00035006}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00035006}.
CC -!- SIMILARITY: Belongs to the calsyntenin family.
CC {ECO:0000256|ARBA:ARBA00035015}.
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DR AlphaFoldDB; A0A3P8W0Y7; -.
DR Ensembl; ENSCSET00000019502.1; ENSCSEP00000019266.1; ENSCSEG00000012265.1.
DR GeneTree; ENSGT00950000183086; -.
DR OMA; PMEDMRG; -.
DR Proteomes; UP000265120; Chromosome 20.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001540; F:amyloid-beta binding; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019894; F:kinesin binding; IEA:InterPro.
DR GO; GO:0042988; F:X11-like protein binding; IEA:InterPro.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 2.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 2.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR026914; Calsyntenin.
DR InterPro; IPR045588; CLSTN_C.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR PANTHER; PTHR14139; CALSYNTENIN; 1.
DR PANTHER; PTHR14139:SF6; CALSYNTENIN-2 ISOFORM X1; 1.
DR Pfam; PF00028; Cadherin; 1.
DR Pfam; PF19699; CLSTN_C; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 2.
DR SUPFAM; SSF49313; Cadherin-like; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS50268; CADHERIN_2; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PROSITE-ProRule:PRU00043};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 756..779
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..86
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 87..187
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 815..887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..865
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 866..880
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 887 AA; 99503 MW; 9143644D033FD4D8 CRC64;
MFFGEICDFK IYGQDAPFKA VVLNRTSGEG VLKASSPVDC ESQKEYTFII QAYDCGSGPN
GADWKKSHKA VVHIQVDDVN EFAPVFREPQ YKASVTEGKI YDSILQVEAW DQDCSPQYSQ
ICNYEIVTPG TPFAIDRNGN IRNTERLSFD KQQSYKIMVT AFDCGQKRAK EDVAVHIVVK
PVCKPGWQGW NKRVDYEPGT GSKQLFPKMH LETCGGPLSG VKAMVELQTN HIGKGCDRET
YSEKSLQKLC GAASGSTDLL PAPSPSTNWT SSLLTDSGRD SDLIYRFDGR QAANVPDHVV
PQNLTDQFTI ATWMKHGPSP GLRAEKETLL CNSDKTEMNR HHYSLYVHNC RLVFLLRRDF
TQVDTFRPAE FHWKLEQICD KEWHYYVINV EFPAVTLFVD GVTYEPYLVT DDWPIHASKI
DTQLTVGACW QGGEVATPRF TQYFRGSLSG LTIRPGRIET QKVISCLQAC KEGLDINSLE
SLAKDIKFHF NPAQSVLVVE GEDVGSINTA MTKVSYINSR QFPTSGLRRL HITTTVQCFG
EDTCLSIPDV KAVVMVLPPS EPRITITGSN RLVRPASDLQ GPLGVAPFKE LHITSTVMKG
DSVGGFHRTG VMEVMHNLDY CDILVIGEEL SPDAESLEIH HNALLGKHLD ATNSTSGISI
YGVDSMAHYE QALRQVRYRN WRPATLTERR FRLTCSELNG RYTSNEFNLE VSLLHHSAPV
EHVNHLASQQ QYIRPVHHPL MIHTLNSHMP GTAPPAATVI IVVCIAALVT IVVIGVYRIH
ATHQEGSRED EEEVKEADVD WENSALTIIV NPMENIAGNQ AVDEEVKEES QEEEEQGMTS
AESENSDEDD EEEEEEEEEE EEEDERDVVE KRKHEGKFEW DSSSSTY
//
