ID A0A3P8W149_CYNSE Unreviewed; 826 AA.
AC A0A3P8W149;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Two pore segment channel 1 {ECO:0000313|Ensembl:ENSCSEP00000020314.1};
GN Name=TPCN1 {ECO:0000313|Ensembl:ENSCSEP00000020314.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000020314.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000020314.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000020314.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_008334958.1; XM_008336736.2.
DR AlphaFoldDB; A0A3P8W149; -.
DR STRING; 244447.ENSCSEP00000020314; -.
DR Ensembl; ENSCSET00000020566.1; ENSCSEP00000020314.1; ENSCSEG00000012960.1.
DR GeneID; 103398205; -.
DR KEGG; csem:103398205; -.
DR CTD; 53373; -.
DR GeneTree; ENSGT00940000158958; -.
DR InParanoid; A0A3P8W149; -.
DR OrthoDB; 5403296at2759; -.
DR Proteomes; UP000265120; Chromosome Z.
DR GO; GO:0005765; C:lysosomal membrane; IEA:InterPro.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0022832; F:voltage-gated channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR028801; TPC1_animal.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46474; TWO PORE CALCIUM CHANNEL PROTEIN 1; 1.
DR PANTHER; PTHR46474:SF1; TWO PORE CHANNEL PROTEIN 1; 1.
DR Pfam; PF00520; Ion_trans; 2.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 104..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 474..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 504..522
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 564..583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 663..688
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 105..325
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 438..688
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 792..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..826
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 826 AA; 95446 MW; F5B0C16135C834E5 CRC64;
MDPDDDVPLI LTCDEANSGL LNEETERGDE NGGEGNYDIV NSAVVSTPGP HNYRTHNVSL
RQSWEMNYQE AAIYLQEGEN NDKFFTHPRN PKALAAYLFA HNHLFYMMEL LTGLLLLMLS
LCEAPAVPSL RLDVYVHATL ELLALVMVAF ELCMKLRWLG FNTFIRHRRT MVKTCVLLLQ
FVEAIVVLIR QTSHMRVTRA LRPIFLVDCR YCGAVRRNLR QMFQSLPSFI DILLLLLFFM
VIFAILGFCL FSTNSADPYF STLENSLVSL FVLLTTANFP DVMMPAYSKN RWSCVFFIVY
LSIELYFIMN LLLAVVFDTF NDVEKMKFKS LLLHKHSAID HAFQLLVSRQ RPTGVSLKQF
DGLMRFYRPR MSARDRFLTF KALDTSGAHM LSLQDFYKFY EVIGLKWKAR RSGEHWFDDL
PHTAFLIFKG INMLVKSKAF QYAMYVVVAI NGVWILVEMY TLKSGFSWSR FVPWSYIVFL
TIYGVEVLLK IAGLGPMAYF SSGWNLFDFL VTVFAFLGLI ALAFNMEPFY FIVVLRPFQL
LRLFKIKQRY RNVLDTMFEL FPRMASLGLT LIIFYYSFAI VGMEFFADVV YPNCCNTSTV
ADSYRQINIT VGNTTVLEEG YYYLNNFNNI LSSFVTLFEL TVVNNWYITM EGVTSMTSHW
SRLYFMTFYI VTMVVMTIIV AFILDAFVFR MNYSRKNREP LENPEDENGI VFEVEVSREE
ALATLELYKR TCPGLSSLSS LQGILQSMDR VGHMSLVYLG RRSRTKSDLS MKMYEEEMQE
WYVEYSRENV PGPDESLPLS LNSPVSNTTP FPVVRPNTQT GPHSIS
//
