ID   A0A3P8W155_CYNSE        Unreviewed;       340 AA.
AC   A0A3P8W155;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=EI24 autophagy associated transmembrane protein {ECO:0000313|Ensembl:ENSCSEP00000020287.1};
OS   Cynoglossus semilaevis (Tongue sole).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC   Cynoglossinae; Cynoglossus.
OX   NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000020287.1, ECO:0000313|Proteomes:UP000265120};
RN   [1] {ECO:0000313|Ensembl:ENSCSEP00000020287.1, ECO:0000313|Proteomes:UP000265120}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24487278;
RA   Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA   Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA   Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA   Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA   Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA   Zhao Y., Schartl M., Tang Q., Wang J.;
RT   "Whole-genome sequence of a flatfish provides insights into ZW sex
RT   chromosome evolution and adaptation to a benthic lifestyle.";
RL   Nat. Genet. 46:253-260(2014).
RN   [2] {ECO:0000313|Ensembl:ENSCSEP00000020287.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the EI24 family.
CC       {ECO:0000256|ARBA:ARBA00010970}.
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DR   AlphaFoldDB; A0A3P8W155; -.
DR   Ensembl; ENSCSET00000020537.1; ENSCSEP00000020287.1; ENSCSEG00000012930.1.
DR   GeneTree; ENSGT00390000018633; -.
DR   Proteomes; UP000265120; Chromosome 19.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   PANTHER; PTHR21389:SF0; ETOPOSIDE-INDUCED PROTEIN 2.4 HOMOLOG; 1.
DR   PANTHER; PTHR21389; P53 INDUCED PROTEIN; 1.
DR   Pfam; PF07264; EI24; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        115..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        175..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        242..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          37..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          320..340
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   340 AA;  38684 MW;  A8E2C254F53D2D68 CRC64;
     MTDSVRAFLR NVATGIKDSI LGIGTISKLD ARIQQKREEQ RKRRASGALA QRRAQNEERK
     PDNEPKVASR IFQCCAWNGG VFWVRNVHHE RFIISVTQSI YCLCPGDPSL HGSVWSWLEF
     ILTSVFSALW VLPLFVLSKV VNAIWFQDIA DLAFEVSGCK AQPFPSVSKI IADMLFNLLL
     QALFLIQGMI VSLFPIDAIG QMVSLLHMSL LYSLYCFEYR WFNHGIEMHQ RLSNIERNWP
     YYFGFGLPMA LLTALPSSYI ISGCLFSILF PLFIISANEA KTPTKLYHFQ LRLFSLVVLI
     SNKLFHKTVH LQSSLTSSTS SERLSTPRTS PSRQRLVATQ
//