ID A0A3P8W3V7_CYNSE Unreviewed; 547 AA.
AC A0A3P8W3V7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=aldehyde dehydrogenase (NAD(+)) {ECO:0000256|ARBA:ARBA00024226};
DE EC=1.2.1.3 {ECO:0000256|ARBA:ARBA00024226};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000021212.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000021212.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000021212.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR AlphaFoldDB; A0A3P8W3V7; -.
DR STRING; 244447.ENSCSEP00000021212; -.
DR Ensembl; ENSCSET00000021485.1; ENSCSEP00000021212.1; ENSCSEG00000013548.1.
DR GeneTree; ENSGT00940000154938; -.
DR InParanoid; A0A3P8W3V7; -.
DR OMA; DAWKVYM; -.
DR Proteomes; UP000265120; Chromosome 2.
DR GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0043878; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; IEA:UniProtKB-EC.
DR CDD; cd07130; ALDH_F7_AASADH; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR044638; ALDH7A1-like.
DR PANTHER; PTHR43521; ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR43521:SF1; ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 71..527
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 304
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 547 AA; 59456 MW; D3D5041E9918983A CRC64;
MLPVLMQRCL TLTFARHSRL LLRHKFATVH CQQTAAMSSL LINQPKYSWL KELGLSEDNH
GVYNGSWVGS GEVVTSYCPA NNEPIARVTQ ATLAEYEETV QKTKEAWKVW ADIPAPKRGE
IVRQIGDALR KKIKVLGSLV SLEMGKIYVE GVGEVQEYVD ICDYAVGLSR MIGGPILPSE
RPGHALIEQW NPVGLVGVIT AFNFPVAVYG WNNALALTCG NVCLWKGAPT TPLTSVAVTK
IVAEVLEANN LPGAICSMTC GGADIGTAMA KDERVDLLSF TGSTHVGKMV GMMVQERFGR
KLLELGGNNA IIVFEDADLN LVVPSAVFAS VGTAGQRCTT TRRLILHESV HDTVVERVAK
AYKQVRIGDP WDPSTLYGPL HTKQAVEQYQ SAIEQAKQQG GTVVCGGKKM DRPGNYVEPT
IITGLAHDAP IVHTETFVPI LYVLKFKTEE EAFALNNEVK QGLSSSIFTK DMGRVFRWLG
PKGSDCGIVN VNIPTSGAEI GGAFGGEKHT GGGRESGSDS WKQYMRRSTC TINYSKDLPL
AQGIKFE
//
