ID A0A3P8W417_CYNSE Unreviewed; 644 AA.
AC A0A3P8W417;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=VWFD domain-containing protein {ECO:0000259|PROSITE:PS51233};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000021272.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000021272.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000021272.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8W417; -.
DR Ensembl; ENSCSET00000021546.1; ENSCSEP00000021272.1; ENSCSEG00000012612.1.
DR GeneTree; ENSGT00940000165245; -.
DR Proteomes; UP000265120; Chromosome 8.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd19941; TIL; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR PANTHER; PTHR11339:SF289; MUCIN-19-LIKE; 1.
DR Pfam; PF08742; C8; 1.
DR Pfam; PF00094; VWD; 2.
DR SMART; SM00832; C8; 1.
DR SMART; SM00215; VWC_out; 1.
DR SMART; SM00216; VWD; 1.
DR SUPFAM; SSF57567; Serine protease inhibitors; 1.
DR PROSITE; PS51233; VWFD; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 334..521
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
SQ SEQUENCE 644 AA; 72707 MW; DE7633FB1BF7BDC3 CRC64;
EYIHMYVYMY LYTIVHIYGC LYLYKYLYIY TCKMFGSGII QTFNASSFHV RTNCPFTLTH
FTHDQVDYDI TTLRGDDGLL SQMEIIVNKI RTVVQIGGIL VEKKRFGCKI ILSLGLYTEP
SLFVSLPYDH TYQHIFQYGT YTRLRSLLFP LSVTWHTLPA GIDTVMVELE QGFSTEMTGL
CGQPNVSSNL FISVSQYSHF STFFFFFQLC NKFFSHTMDC LQDRNPHFLR LCEENMYSYE
SSNYVRCSFF SEVVQQCRHN SYIWIIWRTL TGCAAPTCPG DLVYEEQGAA FVPSCSNFNP
SHSRQNLIRS CVCPEGSVLN DQTDGFHCVN ISKCPCKFAG RSYVSGDKRS TNCQTCVCQA
GGWHCSENSC PPRCLLEGQF VTTFDGKQYA VPGKCAYVAS QGLNWTIMVR FSEKYSSLHT
AVLQLPQVLD HALVFWQSSM FVQVQTSFGM KIQVQMSPEI QLYITLPRNN PYNVSGLCGN
SNNDTTDDFT TSTGIVENSP QPFALSWSVG TCAANIPPIC SSTDSEIFAD EMCSVLRDQT
GIFAKCHDHI PADQFYTTCV GRTCNCGSHL QQCLCVALGS YAKACAILGV AVGDWRKATN
CSKFSLVTRQ LIQVNLSTTN KHRSKQTLRE LLVQCTYEKD DLNS
//
