ID A0A3P8W482_CYNSE Unreviewed; 260 AA.
AC A0A3P8W482;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=DAN domain family member 5-like {ECO:0000313|Ensembl:ENSCSEP00000021337.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000021337.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000021337.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000021337.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|PIRNR:PIRNR027807}.
CC -!- SIMILARITY: Belongs to the DAN family. {ECO:0000256|ARBA:ARBA00007872,
CC ECO:0000256|PIRNR:PIRNR027807}.
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DR RefSeq; XP_008315816.1; XM_008317594.1.
DR AlphaFoldDB; A0A3P8W482; -.
DR STRING; 244447.ENSCSEP00000021337; -.
DR Ensembl; ENSCSET00000021611.1; ENSCSEP00000021337.1; ENSCSEG00000013627.1.
DR GeneID; 103384177; -.
DR KEGG; csem:103384177; -.
DR CTD; 199699; -.
DR GeneTree; ENSGT00530000063926; -.
DR InParanoid; A0A3P8W482; -.
DR OMA; KQTCTAV; -.
DR OrthoDB; 5347549at2759; -.
DR Proteomes; UP000265120; Chromosome 9.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0003002; P:regionalization; IEA:UniProt.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR016860; Cerberus.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR004133; DAN.
DR PANTHER; PTHR15273:SF4; CERBERUS; 1.
DR PANTHER; PTHR15273; DAN DOMAIN FAMILY MEMBER 5; 1.
DR Pfam; PF03045; DAN; 1.
DR PIRSF; PIRSF027807; Cerberus; 1.
DR SMART; SM00041; CT; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Secreted {ECO:0000256|PIRNR:PIRNR027807};
KW Signal {ECO:0000256|PIRNR:PIRNR027807}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|PIRNR:PIRNR027807"
FT CHAIN 20..260
FT /evidence="ECO:0000256|PIRNR:PIRNR027807"
FT /id="PRO_5024528100"
FT DOMAIN 156..248
FT /note="CTCK"
FT /evidence="ECO:0000259|SMART:SM00041"
SQ SEQUENCE 260 AA; 28357 MW; 13A588C62175BEBB CRC64;
MAVLICLFLL SSWTAVTFTF PHHFFDKNIL KISSDDSESS GSGPDEFSRG LVKVVQLDHH
SFPRSGFFRR GLTPKTAPSI RSRVPLPAFL SQGRPGPATG SRAAVSPFNS LHHKSPTVLE
QKKKQGRQMW QTAIGKEDKT MSVPISLKDT KQTCTAVAFT QLVTADGCDS VKIQNKFCFG
QCSSLFVPSE GDFAALGSGL GTYHRRAPCS RCAPSKAHTV TVPLHCGTQI REKRLLVVEE
CKCETGSEER SVEATAPMLL
//
