ID A0A3P8W5L9_CYNSE Unreviewed; 713 AA.
AC A0A3P8W5L9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Circadian locomoter output cycles protein kaput-like {ECO:0000313|Ensembl:ENSCSEP00000021837.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000021837.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000021837.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000021837.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8W5L9; -.
DR Ensembl; ENSCSET00000022116.1; ENSCSEP00000021837.1; ENSCSEG00000013933.1.
DR GeneTree; ENSGT00940000164304; -.
DR OMA; NQSHSAY; -.
DR Proteomes; UP000265120; Chromosome 19.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0032922; P:circadian regulation of gene expression; IEA:InterPro.
DR CDD; cd19736; bHLH-PAS_PASD1; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR047230; CLOCK-like.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR PANTHER; PTHR46055:SF4; CIRCADIAN CLOCK PROTEIN PASD1; 1.
DR PANTHER; PTHR46055; CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 35..87
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 110..173
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 281..328
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 417..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 713 AA; 82054 MW; 8EF6BCF82BD365A8 CRC64;
MDNQSTFIVP CSSTHKDWDN ICMEDMYDED EKDRAKRESR NKSEKKRRDQ FNVLIKELCA
MLQGQGHPHK MDKTTILQRT IDFLQQQKDI TPNKNIRDMR QDWKPAFLSN GDFTQLMLEA
IDGFLVALTT DGNIIYVSDS VSSLTGHLPS DMLDQNILNF LPEQEHRDVY KLLSSPMLIK
DNSENVVEFC CHLARGNTDP QQTPVYEYVK FIGDFKFHNN VPKSTCDSLK VTLHRSLQSA
LEEEICLIAT VQLVTPQFVK DLCNIEDRCD EFISRHSLEW KFLFLDQRAS PVIGYLPFEV
LGTSGYDYYH VDDLEPIAQC HKQLMQFGKG KSCYYRFLTK GQQWIWLQTH YYITYHQWNS
KPEFIVCTHT VVSYSKVRAE KRRAVGLKEL SPSENVLPSV KAQELYLDIC STINPTLDGN
SGAGSPHSSR RSSLTELSDS ASYSYTDTWQ AASTETERTG RLEPCGSKQQ QQPPPIYQPQ
KPRPGIVNQL KEQLEERTRV LQADIKTQQK ELYKIKEKLH TANLQVQQRT GQEGQLQPVT
VSLQTGTSLT MPLFSNPMMF SHTTTRPFHN TNQRHADGFL NHDEQIRYTL EQQITPSLSM
EQVNCNNVLV PSTVFTPPIV VPHNGFMTQQ PPSMHINQHC LQPQQQFEMT RCIPSGSSPT
TLYTSNVPQQ STVEYIQQTM LQPPVRQQQQ LRQHQHFQNP TDAVSGFRNM QTR
//