GenomeNet

Database: UniProt
Entry: A0A3P8W5L9_CYNSE
LinkDB: A0A3P8W5L9_CYNSE
Original site: A0A3P8W5L9_CYNSE 
ID   A0A3P8W5L9_CYNSE        Unreviewed;       713 AA.
AC   A0A3P8W5L9;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Circadian locomoter output cycles protein kaput-like {ECO:0000313|Ensembl:ENSCSEP00000021837.1};
OS   Cynoglossus semilaevis (Tongue sole).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC   Cynoglossinae; Cynoglossus.
OX   NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000021837.1, ECO:0000313|Proteomes:UP000265120};
RN   [1] {ECO:0000313|Ensembl:ENSCSEP00000021837.1, ECO:0000313|Proteomes:UP000265120}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24487278;
RA   Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA   Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA   Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA   Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA   Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA   Zhao Y., Schartl M., Tang Q., Wang J.;
RT   "Whole-genome sequence of a flatfish provides insights into ZW sex
RT   chromosome evolution and adaptation to a benthic lifestyle.";
RL   Nat. Genet. 46:253-260(2014).
RN   [2] {ECO:0000313|Ensembl:ENSCSEP00000021837.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3P8W5L9; -.
DR   Ensembl; ENSCSET00000022116.1; ENSCSEP00000021837.1; ENSCSEG00000013933.1.
DR   GeneTree; ENSGT00940000164304; -.
DR   OMA; NQSHSAY; -.
DR   Proteomes; UP000265120; Chromosome 19.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0032922; P:circadian regulation of gene expression; IEA:InterPro.
DR   CDD; cd19736; bHLH-PAS_PASD1; 1.
DR   CDD; cd00130; PAS; 2.
DR   Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR047230; CLOCK-like.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR001067; Nuc_translocat.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   PANTHER; PTHR46055:SF4; CIRCADIAN CLOCK PROTEIN PASD1; 1.
DR   PANTHER; PTHR46055; CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT; 1.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF00989; PAS; 1.
DR   Pfam; PF14598; PAS_11; 1.
DR   PRINTS; PR00785; NCTRNSLOCATR.
DR   SMART; SM00353; HLH; 1.
DR   SMART; SM00086; PAC; 1.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS50112; PAS; 2.
PE   4: Predicted;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          35..87
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   DOMAIN          110..173
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          281..328
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   REGION          417..437
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          449..483
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          686..713
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   713 AA;  82054 MW;  8EF6BCF82BD365A8 CRC64;
     MDNQSTFIVP CSSTHKDWDN ICMEDMYDED EKDRAKRESR NKSEKKRRDQ FNVLIKELCA
     MLQGQGHPHK MDKTTILQRT IDFLQQQKDI TPNKNIRDMR QDWKPAFLSN GDFTQLMLEA
     IDGFLVALTT DGNIIYVSDS VSSLTGHLPS DMLDQNILNF LPEQEHRDVY KLLSSPMLIK
     DNSENVVEFC CHLARGNTDP QQTPVYEYVK FIGDFKFHNN VPKSTCDSLK VTLHRSLQSA
     LEEEICLIAT VQLVTPQFVK DLCNIEDRCD EFISRHSLEW KFLFLDQRAS PVIGYLPFEV
     LGTSGYDYYH VDDLEPIAQC HKQLMQFGKG KSCYYRFLTK GQQWIWLQTH YYITYHQWNS
     KPEFIVCTHT VVSYSKVRAE KRRAVGLKEL SPSENVLPSV KAQELYLDIC STINPTLDGN
     SGAGSPHSSR RSSLTELSDS ASYSYTDTWQ AASTETERTG RLEPCGSKQQ QQPPPIYQPQ
     KPRPGIVNQL KEQLEERTRV LQADIKTQQK ELYKIKEKLH TANLQVQQRT GQEGQLQPVT
     VSLQTGTSLT MPLFSNPMMF SHTTTRPFHN TNQRHADGFL NHDEQIRYTL EQQITPSLSM
     EQVNCNNVLV PSTVFTPPIV VPHNGFMTQQ PPSMHINQHC LQPQQQFEMT RCIPSGSSPT
     TLYTSNVPQQ STVEYIQQTM LQPPVRQQQQ LRQHQHFQNP TDAVSGFRNM QTR
//
DBGET integrated database retrieval system