ID A0A3P8W5R3_CYNSE Unreviewed; 379 AA.
AC A0A3P8W5R3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Arf-GAP with dual PH domain-containing protein 2-like {ECO:0000313|Ensembl:ENSCSEP00000020921.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000020921.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000020921.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000020921.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8W5R3; -.
DR Ensembl; ENSCSET00000021193.1; ENSCSEP00000020921.1; ENSCSEG00000013343.1.
DR GeneTree; ENSGT00940000156498; -.
DR OMA; RWHCGIS; -.
DR Proteomes; UP000265120; Chromosome 9.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:1902936; F:phosphatidylinositol bisphosphate binding; IEA:InterPro.
DR CDD; cd13252; PH1_ADAP; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037849; PH1_ADAP.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46021; ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN; 1.
DR PANTHER; PTHR46021:SF6; ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 8..121
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 256..363
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 379 AA; 44270 MW; 8DF2CA06AB3087AD CRC64;
MAILERNNKI LLDLARQPGN NKCADCGAPE PDWASYTLGV FVCLSCAGIH RHLPSVSKVK
SIRLDLWDDP LVQFMQERGN SAAKAIFEKC VPVFFYRPQH KDCTVLREQW IRAKYERREF
TGENNYLQQV YASGRFEVTL WKKGKVNKQF LRRIFLLSQK DLTLRYFIKE DSKVPKAVIG
MNDLNAVFQP EKVGHAHGLQ ISYLHDKRIR NLFVYHDDGQ VIVSLFNALR ATRLSYLKKK
HPTFRENDLI PQLTRHCLKE GYMEKTGPTL REPFKKRWFT LCSMNRKLLY FKNPLDATEL
GTVFIGMESY GYSVSERSCS RSTKGGQWHC GITLETPGRQ FVFMCEQEQE QREWLEAFRK
VISQTMTPED YATLRRKQS
//
