ID A0A3P8W7D7_CYNSE Unreviewed; 1303 AA.
AC A0A3P8W7D7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Rho guanine nucleotide exchange factor 12-like {ECO:0000313|Ensembl:ENSCSEP00000023448.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000023448.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000023448.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000023448.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004370}.
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DR Ensembl; ENSCSET00000023756.1; ENSCSEP00000023448.1; ENSCSEG00000014864.1.
DR GeneTree; ENSGT00940000157662; -.
DR Proteomes; UP000265120; Chromosome 19.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR015212; RGS-like_dom.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR45872:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12; 1.
DR PANTHER; PTHR45872; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF09128; RGS-like; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 42..119
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 695..885
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 927..1040
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1069..1114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..155
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1071..1086
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1096..1114
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1303 AA; 146942 MW; B31DB0180B0876E8 CRC64;
WSGCRSTLSV VPVDPGDKKP RNDKSAVSVK HEFDPTGLVQ RCVIIQRDEN GFGLTVSGDN
PVFVQLVKED GAAMRAGVQT GDRIIKVNGT LVTHSNHIEV VKLIKSGSYV ALTVLGRPPG
LPQIPLGEEE EDEEEDQKKA EEEEKEKEEE DEGSEVSPPL CLSPALPGVC GEQRSSWSSS
SPQENSTSSL TDGEEECSRH PRPKLLKEIQ EIKKQISLLQ EQLGKEVGAL LYLLFYESPG
RRETPCQSPD VGRRDIVNLC SMPDSEDNTD TDCSAQCIVG SPPYLLNPQI IGAEDDYFDC
QQEQINGQCS CFQSLDLLKG RPAHLAVFLH HVVSQFDPAP LLCYLYADMH KQTNAKESRR
FFMEFHSLFM DRTANLKVPV PETVSAELEK RRLELIPEEL CKHYTQVLQD ALLPDLHKNL
DDFRQKRSMG LTLAEDELSK LDVDPGREQS ASEKECSFSD LQTMQYVILT YMKHLGVKVK
EPRGLEHKRA RINFLPKIKK SIKSEKEGEE KVKKPRFPNI LVPPRRLSRV DSTSGQRSPK
QSSQPALGAL EQLDSSAGNS GRGRASQLSE SSDTGSHLSL SATSPTHSSP TTQASDTSGQ
ESDSSEKLEG PLTGEQQDNV FSPINAQFDF SPSNLEQLQE EDQETNKKYW FKMTSADIQS
EDDQGGEVEC EGEPLNWQCL VSRGVLESLT PQEIKRQEVI NELFYTERAH LRTLKVMDSV
FYQRLNRDGI LSTEDIRHIF INLEEIVQLH VSVTEQMTAI RKRSETSVID QIGDDLLSWF
SGEEEEKIKQ AVGTFCSNQP SALELIKTKK KKDQRFHLFM QEAESNRLCR RLQLKDLIPV
EMQRLTKYPL LLENIARYTE DGEDKEKVKK AGECCKNILN HVNQAVKEAE NKQRLEDYQR
RLDLSSLKQS ENPMILELKN LDLTKRIMVH EGPLLWKVNK DRKIELYALL LEDILVLLQK
QDERLVLKFH GKNPASAADT KHVFSPVIKL NTVLVRPVAT NNKSFFVLSM SDNGAQIYEL
TAQTVSDRRR WQCLITQCAE AMKAKPHNFK CIFILFKFIF HMHLEKDTTS SADIEASPSS
INPFNGLKSE DEEEELTVAE RQEEEEEEEE ELDEAELEAF LDGKLAERLQ QEESCRNQEA
EGLGLGPPTS KAEEALQTCE SSLYQKVYNT NFCQKVCIMG CFIWCKRDAS LQTKSLSFFV
HLCPPPGGFL VLDFNVGSEE SSTDDDGGFA IDAGIDMRKL LSSSSQTGGT GPNLSRQLMT
HLRLLQADLQ HLKEVELKYN EMRQMHSDPT TDSEDNNGGL IFS
//
