ID A0A3P8W835_CYNSE Unreviewed; 401 AA.
AC A0A3P8W835;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Phosphatidylcholine-sterol acyltransferase {ECO:0000256|ARBA:ARBA00040526};
DE EC=2.3.1.43 {ECO:0000256|ARBA:ARBA00039142};
DE AltName: Full=Lecithin-cholesterol acyltransferase {ECO:0000256|ARBA:ARBA00042279};
DE AltName: Full=Phospholipid-cholesterol acyltransferase {ECO:0000256|ARBA:ARBA00041412};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000021791.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000021791.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000021791.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol = a 1-
CC acyl-sn-glycero-3-phosphocholine + a sterol ester;
CC Xref=Rhea:RHEA:21204, ChEBI:CHEBI:15889, ChEBI:CHEBI:35915,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=2.3.1.43;
CC Evidence={ECO:0000256|ARBA:ARBA00036617};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701}.
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DR AlphaFoldDB; A0A3P8W835; -.
DR STRING; 244447.ENSCSEP00000021791; -.
DR Ensembl; ENSCSET00000022069.1; ENSCSEP00000021791.1; ENSCSEG00000013904.1.
DR GeneTree; ENSGT00940000160052; -.
DR InParanoid; A0A3P8W835; -.
DR OMA; PWQWVPL; -.
DR Proteomes; UP000265120; Chromosome 6.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008374; F:O-acyltransferase activity; IEA:InterPro.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 2.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR003386; LACT/PDAT_acylTrfase.
DR PANTHER; PTHR11440; LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR11440:SF18; PHOSPHATIDYLCHOLINE-STEROL ACYLTRANSFERASE; 1.
DR Pfam; PF02450; LCAT; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166}.
SQ SEQUENCE 401 AA; 46369 MW; 4292C9125445C36C CRC64;
PNLQSAPQDT LIPGNLGNRL EAKVNKPAIV NWFCYKKSEQ WFSLWINLNM LLPVLVDCWI
DNIRLVYDRT TRRSSNSPGV QVRVPGFGQT YPVEFLDNNR LTGYFHTMVN HLVNMGYVRN
ETVRSAPYDW RLAPNENVEY FQQLKDLVEE MYEQHQHPVY LLGHSMGCHY TLYFLNHQPQ
TWKDKYIKGF ISLGAPWGGA VKALRVLASG NNDGVPMISN MKIREEQRMT VTNLWLLPLQ
SVRAKDHVFI STPTFNYTGQ DYNRFFMDIG FEDGWYMWED TKNLTGDLQA PGVEVWCMYG
VGLPTPVTYI YDEKFPDEDP VDYVYADGDD TVDSLSMSLC KRWVGEQDKP VHVTEYRGLP
HLDIVYNEKV LTQIQQILEG ISETPEEIDA RPDTRGKRTG N
//
