ID A0A3P8W8Z7_CYNSE Unreviewed; 727 AA.
AC A0A3P8W8Z7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Cytoplasmic polyadenylation element binding protein 4 {ECO:0000313|Ensembl:ENSCSEP00000023124.1};
GN Name=CPEB4 {ECO:0000313|Ensembl:ENSCSEP00000023124.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000023124.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000023124.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000023124.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RRM CPEB family.
CC {ECO:0000256|ARBA:ARBA00010347}.
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DR AlphaFoldDB; A0A3P8W8Z7; -.
DR Ensembl; ENSCSET00000023428.1; ENSCSEP00000023124.1; ENSCSEG00000014712.1.
DR GeneTree; ENSGT00940000154998; -.
DR Proteomes; UP000265120; Chromosome 19.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IEA:InterPro.
DR GO; GO:0045182; F:translation regulator activity; IEA:InterPro.
DR CDD; cd19757; Bbox1; 1.
DR CDD; cd12724; RRM1_CPEB2_like; 1.
DR CDD; cd12726; RRM2_CPEB2_like; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 4.10.640.40; Cytoplasmic polyadenylation element-binding protein, ZZ domain; 1.
DR InterPro; IPR032296; CEBP_ZZ.
DR InterPro; IPR038446; CEBP_ZZ_sf.
DR InterPro; IPR034819; CPEB.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR12566; CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB; 1.
DR PANTHER; PTHR12566:SF2; CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 4; 1.
DR Pfam; PF16366; CEBP_ZZ; 1.
DR Pfam; PF16367; RRM_7; 1.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 470..557
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 578..656
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 47..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 224..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..279
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 727 AA; 79433 MW; 423177F93A5D2B9B CRC64;
MGDYGFGVLV QNNTGNKSAF PVRIHPHLQP PHHHQNVSQS PAAFINSTTA AGNGTTGGSP
WLFPASATHN SVQDEILGGG EKPKAQQQQE MQETQEKQQQ LSPGSHQDSG SGGGIISELE
KARSEEAKTD NGTSEVSNGK EKQLRLESPV LPGFDYQETS GLGTGPVQSS TTSSSLTGFN
NWSAAIPPAP STIINEDVSF FNPASANNGP LLFQNFSHHV SPGFGGNFSP QIGPAAALSQ
HHPAPPPHPH FQHPHNQHQQ HRRSPASPHP PPPFPHRNPA FNQLPHLSNS LNKPPSPWGP
ASYQSPSPSP GSSTSWSPGG GYGSGGGGWG GTQGRDYRRG LNGGMTPINS ISPLKKTFPN
NHVASQKYPR NSPAGFNPKS WVDDGVGRSD NIFPFQERTR SFDSFNMNTL ESSLIDIMRA
EQDTLKGHSS LFPMEDGFPD DERGDQGLAG LGSPHCFPHQ NGERVERYSR KVFVGGLPPD
IDEDEITASF RRFGHLFVDW PHKAESKSYF PPKGYAFLLF QDESSVQALI DACIEEDGKL
YLCVSSPTIK DKPVQIRPWN LNDSDFVMDG SQPLDPRKTI FVGGVPRPVR AVELAMIMDR
LYGGVCYAGI DTDPELKYPK GAGRVAFSNQ QSYIAAISAR FVQLQHGEID KRVEVKPYVL
DDQLCDECQG TRCGGKFAPF FCANVTCLQY YCEYCWAAIH SRAGREFHKP LVKEGGDRPR
HISFRWN
//
