ID A0A3P8W9M9_CYNSE Unreviewed; 795 AA.
AC A0A3P8W9M9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Cullin-5 {ECO:0000256|ARBA:ARBA00040451};
GN Name=CUL5 {ECO:0000313|Ensembl:ENSCSEP00000024228.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000024228.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000024228.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000024228.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR RefSeq; XP_008331257.1; XM_008333035.2.
DR AlphaFoldDB; A0A3P8W9M9; -.
DR STRING; 244447.ENSCSEP00000024228; -.
DR Ensembl; ENSCSET00000024554.1; ENSCSEP00000024228.1; ENSCSEG00000015456.1.
DR GeneID; 103395362; -.
DR KEGG; csem:103395362; -.
DR CTD; 100006147; -.
DR GeneTree; ENSGT00940000156648; -.
DR InParanoid; A0A3P8W9M9; -.
DR OMA; MEQQIIL; -.
DR OrthoDB; 5474206at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000265120; Chromosome 19.
DR GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016157; Cullin_CS.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF76; CULLIN-5; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01256; CULLIN_1; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 418..653
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
SQ SEQUENCE 795 AA; 92477 MW; 75385A415971848C CRC64;
MATSNLLKNK GSLQFEDKWD LMRPIVLKLL RQESVTKQQW FDLFSDVHAV CLWDDKGPAK
IHQALKEDIL DFIKQAQARV LSHQDDTALL KAYIVEWRKF FTQCDILPKP FCQLEITLMG
KQGSNKKSNV EDSIVRKLML DTWNESIFSN IKNRLQDSAM KLVHAERLGE AFDSQLVIGV
RESYVNLCSN PDDKLQIYRD NFEKAYMDST ERFYRTQAPA YLQQNGVQNY MKYADSKLRE
EEKRALRYLE TRRDCNSVQA LMECCVNALV TSFKETILAE CPGMIKRNET ESEYGRTAST
KGSASSELHL MFSLMDKVPN GIEPMLKDLE EHIMSAGLAD MVASAETITS DSEKYVEQLL
TLFNRFSRLV KEAFQDDPRF LTARDKAYKA VVNDATIFKL ELPMKQKGVG LKTQPESKCP
ELLANYCDML LRKTPLSKKL TSEEIEAKLK EVLLVLKYVQ NKDVFMRYHK AHLTRRLILD
ISADSEIEEN MVEWLREVGM PADYVNKLAR MFQDIKVSED LNQSFKEMHK HNKLALPADS
VNIKILNAGA WSRSSEKVFV SLPTELEDLI PEVEDFYKKN HSGRKLHWHH LMSNGIITFK
NEVGQYDLEV TTFQLAVLFA WNQRPRERIS FENLKLATEL PDAELRRTLW SLVAFPKLKR
QVLSYDPVVS SPKDFAEGTL FYVNQEFSLI KNSKVQKRGK INLIGRLQLT TERMREEENE
GIVQLRILRT QEAIIQIMKM RKRINNAQLQ TELVEILKNM FLPQKKMIKE QIEWLIDHKY
IKRDETDINT FIYMA
//
