ID A0A3P8W9R3_CYNSE Unreviewed; 611 AA.
AC A0A3P8W9R3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=DAB adaptor protein 2 {ECO:0000313|Ensembl:ENSCSEP00000021300.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000021300.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000021300.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000021300.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P8W9R3; -.
DR Ensembl; ENSCSET00000021574.1; ENSCSEP00000021300.1; ENSCSEG00000013563.1.
DR GeneTree; ENSGT00940000155567; -.
DR OMA; IQAPNSA; -.
DR Proteomes; UP000265120; Chromosome 14.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR CDD; cd01215; PTB_Dab; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR048559; DAB1/2_SBM.
DR InterPro; IPR048561; Dab_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR PANTHER; PTHR47695:SF5; DISABLED HOMOLOG 2; 1.
DR PANTHER; PTHR47695; PID DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF21792; DAB2_SBM; 1.
DR Pfam; PF00640; PID; 1.
DR SMART; SM00462; PTB; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01179; PID; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 60..192
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 391..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..410
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 611 AA; 64555 MW; 26555DA596A916B4 CRC64;
MSAEVENSVP ADSNPASPTT GSTSTTPPAS PATATSKIPF KKEKKVPEKT DEYLLSRFKG
DGVRYKAKLI GIDDVSDARG DKMCQDSMMK LKGMAVAARS QGKHKQRIWV NISMSGIKII
DEKSGVIEHE HVVNKISFIA RDVTDNRAFG YVCGAEGQHQ FFAIKTAQQA EPLVVDLKDL
FQVIFNIRKK EAKTTQKGEN GSVVVENGND ALLNFNNEAK AAQPVEELNL FGAVSTPPDI
QAPNSTGSDL FGAELFAAPV QSEASVAPHD LFNSAAANSA PSSLAALGNL QLNAPAATSV
PAVNMWGAST APPSMFPMPG VTAPGPMPHY QQPSGFGGVP IPPTAWGQPG PSQFGAPPHA
WGQPPPAVLP GTAGWGQPAT TNPFHAGPFP VMGEQPGPAR PPPRPPAKEA PPKVENSAFT
ALDPLGDKEK KSGKDMFKDF QIAKPPAIPA RKGELASSVA PASSSSEAGA FDQYFSSKVG
VAQDAADHDD FDINQMSAVV NDVPKPAPAA NPPPSFTSGL LGDAFSQGQS LNQNMFDDAF
GAPTSSPFGM PVVRVGKKEA KFTPTICLDK ITLVLVFVLS RNRRRLLVRV LVQPPLMILL
EIPSLDNRPN S
//
