ID A0A3P8WAY0_CYNSE Unreviewed; 669 AA.
AC A0A3P8WAY0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Carboxypeptidase Z-like {ECO:0000313|Ensembl:ENSCSEP00000021750.1};
GN Name=CPZ {ECO:0000313|Ensembl:ENSCSEP00000021750.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000021750.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000021750.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000021750.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M14 family.
CC {ECO:0000256|ARBA:ARBA00005988}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR RefSeq; XP_008315828.1; XM_008317606.1.
DR AlphaFoldDB; A0A3P8WAY0; -.
DR STRING; 244447.ENSCSEP00000021750; -.
DR Ensembl; ENSCSET00000022027.1; ENSCSEP00000021750.1; ENSCSEG00000013882.1.
DR GeneID; 103384186; -.
DR KEGG; csem:103384186; -.
DR CTD; 8532; -.
DR GeneTree; ENSGT00940000156391; -.
DR InParanoid; A0A3P8WAY0; -.
DR OMA; VEAWPNK; -.
DR OrthoDB; 5490979at2759; -.
DR Proteomes; UP000265120; Chromosome 9.
DR GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd11308; Peptidase_M14NE-CP-C_like; 1.
DR Gene3D; 2.60.40.1120; Carboxypeptidase-like, regulatory domain; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR000834; Peptidase_M14.
DR PANTHER; PTHR11532:SF63; CARBOXYPEPTIDASE Z; 1.
DR PANTHER; PTHR11532; PROTEASE M14 CARBOXYPEPTIDASE; 1.
DR Pfam; PF13620; CarboxypepD_reg; 1.
DR Pfam; PF01392; Fz; 1.
DR Pfam; PF00246; Peptidase_M14; 1.
DR PRINTS; PR00765; CRBOXYPTASEA.
DR SMART; SM00063; FRI; 1.
DR SMART; SM00631; Zn_pept; 1.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS00132; CARBOXYPEPT_ZN_1; 1.
DR PROSITE; PS00133; CARBOXYPEPT_ZN_2; 1.
DR PROSITE; PS50038; FZ; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090}; Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..669
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018184846"
FT DOMAIN 45..167
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DISULFID 129..153
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 669 AA; 76080 MW; BF4E4F699C8A8793 CRC64;
MHSGLLLLFL LSLTERGCSA PQLQGCEPGD ELSGRCSSSS LNVYEEKPKC TQLHLGYCND
LGYSSTIFPN ILGHRSRMDA ESGAEYLLLS VIHGLLNGEC TPEIRLVGCS VLASPCRNDK
MIKPCRSTCE ALRKDCIHAF EAIEMAWPYF LDCDRFFAGA EEGCYDPLAA MRARQELTRS
NLPPEEPSTI IQFTYTTNAQ MYNILKKTAA KCSHISQVYS IGRSTEGKDL LVIEFSNNPG
QHELLEPEVK MLGNMHGNEV LGRQLLIYLA QYLCSEYILG NQRIQTIINT TRIHLLASMN
PDGYELAAAE VEDRNDPDLS YQEGHLMNGW ISGRANAQNL DLNRNFPDLT SIFYRNRRSR
FYRIDHIPIP DSYWFGKVAP ETYAVMKWIR SLPFVQSASL HGGDLVVSYP FDFSRHPQEE
RMFSPTPDEQ IFKQLARTYA DAHATMANND TERCGASFYR TRGIINGAQW YSFAGGMSDF
NYLHTNCLEI TVELGCDKFP SEVELYPEWK RNKESLLSFL ESVHRGIKGV VKDLDGNGIK
GATLSVRGIR KDVTTAEDGD YWRLLNPGTH ILTVTAKGYS RVSKRVHIPH NMNHAGRVDF
VLEKVPVEPD IHDHLFPTVD SWDRFDPYNQ FERYSNAELQ EVEQEEKPWW WNYFSQSGAS
PPHWLLRNV
//
