ID A0A3P8WBA3_CYNSE Unreviewed; 476 AA.
AC A0A3P8WBA3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Fizzy-related protein homolog {ECO:0000313|Ensembl:ENSCSEP00000021895.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000021895.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000021895.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000021895.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat CDC20/Fizzy family.
CC {ECO:0000256|ARBA:ARBA00006445}.
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DR RefSeq; XP_008328545.1; XM_008330323.2.
DR AlphaFoldDB; A0A3P8WBA3; -.
DR STRING; 244447.ENSCSEP00000021895; -.
DR Ensembl; ENSCSET00000022174.1; ENSCSEP00000021895.1; ENSCSEG00000013973.1.
DR GeneID; 103393369; -.
DR GeneTree; ENSGT00950000183104; -.
DR InParanoid; A0A3P8WBA3; -.
DR OrthoDB; 20041at2759; -.
DR Proteomes; UP000265120; Chromosome 2.
DR GO; GO:0010997; F:anaphase-promoting complex binding; IEA:InterPro.
DR GO; GO:0097027; F:ubiquitin-protein transferase activator activity; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR033010; Cdc20/Fizzy.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19918; CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED; 1.
DR PANTHER; PTHR19918:SF34; FIZZY_CELL DIVISION CYCLE 20 RELATED 1 (DROSOPHILA); 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT REPEAT 206..247
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 208..262
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 290..331
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 15..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 476 AA; 52741 MW; 4861615A59745623 CRC64;
MNSDYEHRII RQIHIQNNGS DPASSPRQTG TSSPFSSRTF GDRFIPTRAG ANWDISFHWN
KENEKVTHSD ASPGNVKDGL TYTALLKNEL LGAGIENVQE PQTPKRSLFS YSPHTKRPSL
ETCANISPYS LSTVSNTSHT LLGAPRRPTR KVSESPFKVL DASGLQDDFY LNLVDWSSLN
VLGVGLGSCV YMWSAYTSQV VKLCDLSPEG DSVTSVAWTE RGDLMAVGTH RGYVQIWDAA
TGKKICVWKG HRNRVGVLAW NSDQLSSGSC DCTILQRDTR TSPLQSVRRL KAHKREVCGL
KWNSDRKLLA SGDNDNKLLV WNQDSPMPLQ TFKEHQGAVK AIAWSPHQRS LLASGGGSAD
CSIRIWSSLQ LEPVQRVDTG SQVCNLVWSK HTNELVSTHG YADNKVMVWK CPSLTQVASL
THHSDRVLHL AMSPDGEVIV TGAGGKDETL CFWKLFSNTR STKDLVSNLN LFTRMR
//
