ID A0A3P8WBD4_CYNSE Unreviewed; 421 AA.
AC A0A3P8WBD4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Growth differentiation factor 9 {ECO:0000313|Ensembl:ENSCSEP00000023959.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000023959.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000023959.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000023959.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_008325614.1; XM_008327392.2.
DR AlphaFoldDB; A0A3P8WBD4; -.
DR STRING; 244447.ENSCSEP00000023959; -.
DR Ensembl; ENSCSET00000024279.1; ENSCSEP00000023959.1; ENSCSEG00000015272.1.
DR GeneID; 103391217; -.
DR KEGG; csem:103391217; -.
DR CTD; 2661; -.
DR GeneTree; ENSGT00940000159784; -.
DR InParanoid; A0A3P8WBD4; -.
DR OMA; TWRICVC; -.
DR OrthoDB; 5301288at2759; -.
DR Proteomes; UP000265120; Chromosome 15.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF19; GROWTH_DIFFERENTIATION FACTOR 9; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..421
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018268330"
FT DOMAIN 297..421
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 421 AA; 48589 MW; AE6DB73D5A051362 CRC64;
MEKHVLMSAA LRHVGTVVVL LLLTHTSPEL VTSTTVRSLD ELSSSYSSIF SPLFKALSEH
GGPRWSPALK KKMKPEHRYI KFLSQVYKRS SRVQRSLDGN KTYNTVRLIK PKDECLAQGD
KVSYMQDLSF SLDQVRRREQ LLKSALLYHL DDGHAAPLNT ICYMSVREQE QLNQCHLCPV
IQQAVNFTAD RRNRKNWVEV DITSVVKPLL KFQKKNIQLL VNVTCPDKRV VKEVTLKPPP
LLLYLKDTSK TTQRPLASEK PGASAAAESF HKQIMFRPEQ KFRHKRRWKR HALKSKRGDR
SFDVHLPDLR SPSEFPTKDC ALYDFRVCFS QLKLDHWIVF PPKYNPRYCR GICPKTLGFI
YGSPVHTMVQ NIIYEKLDSS VPQPSCVPSH YSPLSVMIFE EDGSYVYKEF EDMVATRCTC
R
//
