ID A0A3P8WC31_CYNSE Unreviewed; 806 AA.
AC A0A3P8WC31;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Spondin-1 {ECO:0000256|ARBA:ARBA00019594};
DE AltName: Full=F-spondin {ECO:0000256|ARBA:ARBA00030964};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000023206.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000023206.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000023206.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR RefSeq; XP_008308860.1; XM_008310638.2.
DR AlphaFoldDB; A0A3P8WC31; -.
DR STRING; 244447.ENSCSEP00000023206; -.
DR Ensembl; ENSCSET00000023511.1; ENSCSEP00000023206.1; ENSCSEG00000014787.1.
DR GeneID; 103379170; -.
DR KEGG; csem:103379170; -.
DR CTD; 58027; -.
DR GeneTree; ENSGT00940000154910; -.
DR InParanoid; A0A3P8WC31; -.
DR OrthoDB; 5404502at2759; -.
DR Proteomes; UP000265120; Chromosome 5.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd08544; Reeler; 1.
DR Gene3D; 2.60.40.2130; F-spondin domain; 1.
DR Gene3D; 2.60.40.4060; Reeler domain; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 6.
DR InterPro; IPR002861; Reeler_dom.
DR InterPro; IPR042307; Reeler_sf.
DR InterPro; IPR009465; Spondin_N.
DR InterPro; IPR038678; Spondin_N_sf.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR044004; TSP1_spondin_dom.
DR NCBIfam; NF038123; NF038123_dom; 1.
DR PANTHER; PTHR11311; SPONDIN; 1.
DR PANTHER; PTHR11311:SF16; SPONDIN-1; 1.
DR Pfam; PF02014; Reeler; 1.
DR Pfam; PF06468; Spond_N; 1.
DR Pfam; PF19028; TSP1_spondin; 1.
DR Pfam; PF00090; TSP_1; 5.
DR SMART; SM00209; TSP1; 6.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 6.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS51019; REELIN; 1.
DR PROSITE; PS51020; SPONDIN; 1.
DR PROSITE; PS50092; TSP1; 6.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..806
FT /note="Spondin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018032621"
FT DOMAIN 27..193
FT /note="Reelin"
FT /evidence="ECO:0000259|PROSITE:PS51019"
FT DOMAIN 193..386
FT /note="Spondin"
FT /evidence="ECO:0000259|PROSITE:PS51020"
FT REGION 718..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..750
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 806 AA; 90705 MW; 7F63F5FDAE7C03D8 CRC64;
MNPTGLRLRA VLLLCFVSST ACNMFAFTEE PSDRVGKGDG YCSRILRAQS NRREENDDFR
LRVEGDPESY QPGNTYRVTV TASRSAYFRG FTLIALKEGA EGDSDEDYAG NFQIIDEEET
QFMTNCPPAV TESTPRRRTS IQVFWTAPPS GSGCIYLKAS IVQKRIIYFQ DEGPLTKRMC
EKESLYGNIT EKPLLDCCAC GTAKYRVTFF GNWSEKIHPK DYPRRANHWS AIIGSSHSKN
YVLWEYGGFA SDGVKQVAEL GSPVKMEEEI RQKGDDVLTV IKMKAQWPAW QPLNVRAAPS
AEFSVDRTRH LMSFLTMLGP SPDWNVGLSA EDLCTKECGW AQKVVQDLIP WDAGTDSGVS
YESPNKVTEP QDKIRPLTSL DHPQSPFYDP EGGAITPVAR VMVERIARKG EQCNIVPDNV
DDIVADIAQE EKEEDDTPET CIYSNWSPWS ACSSATCDKG KRMRQRMLKA QLDLSVPCPH
TQDFEPCMGP GCSDEDASTC MMSEWITWSP CSASCGLGLR SRERYVKQFP EDGSICTMPT
EETEDCVVNE ECTPSSCLVT EWAEWDLCSA TCGLGMKRRE RMVKMPPEDG SICGAEVLEV
EKCMMPECDT IPCLLSPWSD WSDCSVTCGK GLRTRQRKLK SPVELGDCTE ELEQVEKCML
PECPIDCIMS EWTEWSECNK SCGKGHTIRT RMVMMEPQFG GNPCPESIQR KKCKVRKCSR
GQSNGDDKKR RKEQRDKRRS KLDGAEITSE HPGCKMRPWS SWTECTKLCG GGIQERLMTV
KQRFKTSQLS SCKDRKEIRA CNVHPC
//
