ID A0A3P8WCZ8_CYNSE Unreviewed; 1047 AA.
AC A0A3P8WCZ8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Protein tyrosine kinase 7 (inactive) {ECO:0000313|Ensembl:ENSCSEP00000023496.1};
GN Name=PTK7 {ECO:0000313|Ensembl:ENSCSEP00000023496.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000023496.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000023496.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000023496.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A3P8WCZ8; -.
DR STRING; 244447.ENSCSEP00000023496; -.
DR Ensembl; ENSCSET00000023803.1; ENSCSEP00000023496.1; ENSCSEG00000014972.1.
DR GeneTree; ENSGT00940000157908; -.
DR InParanoid; A0A3P8WCZ8; -.
DR Proteomes; UP000265120; Chromosome 12.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05046; PTK_CCK4; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR PANTHER; PTHR45080; CONTACTIN 5; 1.
DR PANTHER; PTHR45080:SF21; INACTIVE TYROSINE-PROTEIN KINASE 7; 1.
DR Pfam; PF07679; I-set; 4.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 6.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50835; IG_LIKE; 6.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 680..701
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 94..199
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 208..294
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 299..383
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 388..474
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 483..564
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 569..653
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 773..1039
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
SQ SEQUENCE 1047 AA; 117320 MW; 3D24216B2FF6F1D6 CRC64;
MGCPLYVHKK HSKGPAHSAV SVGQWNADVS RASGVVSSLL FLSALESQRC HNHWHCPSSH
QGRTKRQPLN PIFSPVLLLS CYSCLSMSWS VPYPPPADFS VCFLFFTGLE SGNVTLKEPT
SEGEIESSST VILRCLIDGH PRPTCQWFKD GVKLTEKTHQ INNKERTLTF KSASPDDNGL
YYCCAKNAAG HVCSSSNFTL NIIDKSFPRA VVTPEDQVVL KNEEAMFHCQ FTAEPAPTLE
WFHQNELLAN KSRVILLQNG SLVITQVKPR NTGTYKCVGR GLRGSQVTLE ASLLIAELED
VVPTMSKVFT ADTLQRVPCR PPRGRPEPKV WWERGGQPVP TEGRVYQDGL DLVFSPTEEG
DSGTYTCVAQ NKAGRRTHEV TFTVATAPVW VTKPQDSFLD ESKPGYLHCH AQANPEPEVT
WYRNNIMVTP EDSRFKLFPN GTLRINNVEV YDGQIYACET KTVAGRLTGQ ARVSVLEKLK
FTPTPQLSQC LELDNDITIQ CSAKGREPPT IRWTKADGGE LPPHVDQRNG QLHFTKVTRN
DAGNYTCIAT NSLQGEIRAL VTLTVAVYVR FKVDPENTTV YQGHTAVLHC QASSDPEPHI
HWMVKDKTLD ISKDRRFQKM PNGSLVIRDV TTDDTGRYTC VAGNSCSIKD RVAMLYVVDK
PVQFNEEDGD KAPYKMIQTI GLSVGAAVAY IIVVLGLMFY CKKRRNAKRQ PKGQDGEEPE
MECLNGGAVQ QNGHTTAEIQ EEVALTNMGT MATTEKRQSH INNDKLHFPR ANLQTITTLG
KGEFGEVLLS KAKGIEESET ETVVLVKSLQ TRDEQLQLDF KREAEMFAKL SHQNVVRLLG
LCREAEPHYM ILEYYDLGDL KQFLRISRNK DDKIKSQPIS TKTKVSICAQ VAHGMEHLSN
HRFVHKDLAA RNCLINSQRR IKVSSLSLSK DVYNSEYYHY RQAWIPLRWL PSESVFEDDF
STKSDVWAFG VLMWEVFSHG EMPHSKLSDD EVLEGLKAGK LKLPVPDGCP SKIYKLMVRC
WALSLKERPS FADIVHTLGD LPSDSKV
//