ID A0A3P8WD85_CYNSE Unreviewed; 639 AA.
AC A0A3P8WD85;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Adhesion G protein-coupled receptor D1 {ECO:0000313|Ensembl:ENSCSEP00000025408.1};
GN Name=ADGRD1 {ECO:0000313|Ensembl:ENSCSEP00000025408.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000025408.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000025408.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P8WD85; -.
DR Ensembl; ENSCSET00000025745.1; ENSCSEP00000025408.1; ENSCSEG00000016163.1.
DR GeneTree; ENSGT00940000159783; -.
DR Proteomes; UP000265120; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF216; ADHESION G-PROTEIN COUPLED RECEPTOR D1; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 458..477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 489..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 416..537
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 610..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 639 AA; 72426 MW; EC6811CB6C63BD4E CRC64;
VTADVFFPPR WVPAAELLLW NFSDADAETR SLQVLAKASH YWPLEVVKGI RELWDKKGNR
PDIVEGMVNK GILLDGDNGA TFLHFGNYQN TCISDPTLCG PQGITFSFFW KNHEAESRFA
VSSGGKVISN GFSVYTNPFV GYVEFYTRGN NHRWKTNISV PGPYWTHILF TWTRRDGLKV
YINGTFTAAD QVGKVSDSYG DRYSDLVIGT GNDGTYGHFA SGAFDEFVIW EMALSPNDVL
LYYKAATGRR RTAGPTNRRQ EDSPHGWMDL VIYFVIYLDI YFVMYLVIYL NYNLQHYRFP
PEGKSYISVP GEAFTTVSFW TSRLRPLFLS RRISEAVNFK DHKIQVASRL ISLNVEPSPA
LSVNLSGAPL VRIVLTHVLT KDQQDQVQNQ SNKVFLYCAF LDYSTNEGVW SNQGCVRSDG
NMTYSVCLCN HLTNFAILMQ VVTQRFLWSV STICNQRYHI HANLSFAILV AEILLLISAR
FEPGTMPCVV MAVLLHFFFL SAFAWMLVEG LHLYSMVVKV FGSEGSKHAY YYGIGWGGSV
HTRHRHCPLL VGLCDGDYWS CQEGFFVFLF HCLLNSEVRT AFKHKTKVWT LTSSSIRNVN
VKPLNSDIMN ANRDGPSPTK MNTWDKSSNS ANRFDLTAI
//
