ID A0A3P8WD91_CYNSE Unreviewed; 938 AA.
AC A0A3P8WD91;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Aminopeptidase {ECO:0000256|RuleBase:RU364040};
DE EC=3.4.11.- {ECO:0000256|RuleBase:RU364040};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000024407.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000024407.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000024407.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRSR:PIRSR634016-3,
CC ECO:0000256|RuleBase:RU364040};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR634016-3,
CC ECO:0000256|RuleBase:RU364040};
CC -!- SIMILARITY: Belongs to the peptidase M1 family.
CC {ECO:0000256|ARBA:ARBA00010136, ECO:0000256|RuleBase:RU364040}.
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DR RefSeq; XP_008335053.1; XM_008336831.2.
DR AlphaFoldDB; A0A3P8WD91; -.
DR STRING; 244447.ENSCSEP00000024407; -.
DR Ensembl; ENSCSET00000024737.1; ENSCSEP00000024407.1; ENSCSEG00000015587.1.
DR GeneID; 103398274; -.
DR KEGG; csem:103398274; -.
DR CTD; 64167; -.
DR GeneTree; ENSGT00940000162653; -.
DR InParanoid; A0A3P8WD91; -.
DR OMA; NVWMNMS; -.
DR OrthoDB; 3085317at2759; -.
DR Proteomes; UP000265120; Chromosome Z.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd09601; M1_APN-Q_like; 1.
DR Gene3D; 1.25.50.20; -; 1.
DR Gene3D; 2.60.40.1910; -; 1.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR Gene3D; 2.60.40.1730; tricorn interacting facor f3 domain; 1.
DR InterPro; IPR045357; Aminopeptidase_N-like_N.
DR InterPro; IPR042097; Aminopeptidase_N-like_N_sf.
DR InterPro; IPR024571; ERAP1-like_C_dom.
DR InterPro; IPR034016; M1_APN-typ.
DR InterPro; IPR001930; Peptidase_M1.
DR InterPro; IPR014782; Peptidase_M1_dom.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR PANTHER; PTHR11533:SF239; ENDOPLASMIC RETICULUM AMINOPEPTIDASE 2; 1.
DR PANTHER; PTHR11533; PROTEASE M1 ZINC METALLOPROTEASE; 1.
DR Pfam; PF11838; ERAP1_C; 1.
DR Pfam; PF01433; Peptidase_M1; 1.
DR Pfam; PF17900; Peptidase_M1_N; 1.
DR PRINTS; PR00756; ALADIPTASE.
DR SUPFAM; SSF63737; Leukotriene A4 hydrolase N-terminal domain; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000256|RuleBase:RU364040};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU364040};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR634016-3};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU364040};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU364040};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Signal {ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRSR:PIRSR634016-3}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..938
FT /note="Aminopeptidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018111730"
FT DOMAIN 54..240
FT /note="Aminopeptidase N-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17900"
FT DOMAIN 275..481
FT /note="Peptidase M1 membrane alanine aminopeptidase"
FT /evidence="ECO:0000259|Pfam:PF01433"
FT DOMAIN 597..916
FT /note="ERAP1-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF11838"
FT ACT_SITE 348
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR634016-1"
FT BINDING 347
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR634016-3"
FT BINDING 351
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR634016-3"
FT BINDING 370
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR634016-3"
FT SITE 432
FT /note="Transition state stabilizer"
FT /evidence="ECO:0000256|PIRSR:PIRSR634016-4"
SQ SEQUENCE 938 AA; 107632 MW; 0D8EA9D87D804294 CRC64;
MASVRLLLLF LFNLPLAECW SSPGSTNTLG EPSVDTHNLS FPWSRLRLPR YVIPLHYRLL
LHPNLTSLSF TGSVQIQIAV QNNTNWIVLH SKGLQISRAT ILDQNLSPLS DQVLPVLYKP
SHEQIGIFSP RVLSTGPTYF LYIEFGADIA EGFSGFYRST YRTTAGKTRT LASTHFEPTD
ARTAFPCFDE PNFKANFSVR IRRSPAHIAL SNMPVDRTVK VNSELLEDRF AVSVKMSTYL
VAFVICDFRS ISATTSTGVK VSIYAAPEKW PQTHYALDVA VKMLDFYEKY FNIRYPLPKQ
DLIAIPDFQS GAMENWGLTT YRETSLLFDP LTSSLHDKLW VTMVIGHELA HQWFGNLVTM
VWWNDIWLNE GFARYMEYIS VEGTYPELAV EEYLLHTCFA AVGLDSLNSS RPISNAAESP
TQIEEMFDTV SYDKGACVLH MLRYFLTDDV FQSGIVRYLR KYSYKNAQNQ DLWDSLSNTC
TEDDFVSGKH CYTSEHATRN AYMFAGEHLN LTAMMNTWTL QKGVPLVTVT RRGPRLLIRQ
NRFLRTVMPS DPLWPSLQKG FLWHIPLTYK TNGSSLIHRH LMTTHTDSIH VGEEVSWVKV
NTDMTGYYLV HYEDGGWDNM IDLLRENHTA LSYKDRTHLI HNAFQLVTAG HLPIHKALDL
ISYLQKETNT VPLLEGLGYL DAFYHLIEKR NEPELTHILG SYILRFFREV INQQTWSDEG
TVSQRRLRSE VLSLACHLSD PSCIQQAKSI FKDWLHSNGT LNLPTDVAQT VYSVGAQDDH
GWKTLLHTYN FSLSEVLKDK ILHALSRSTD ISKLERLLQL GLEGNVIRMQ DLSHVVLMVA
RNPQGHHLSW NFVKKNWDML VKKFHLGSFS IRNILIGTTS QFSTQEELND VQRFFESIKE
QASELRATQV ALDNVQKNVR WIQRNLETLR KWLSDRVK
//