ID A0A3P8WDT2_CYNSE Unreviewed; 672 AA.
AC A0A3P8WDT2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000024849.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000024849.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000024849.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3P8WDT2; -.
DR STRING; 244447.ENSCSEP00000024849; -.
DR Ensembl; ENSCSET00000025181.1; ENSCSEP00000024849.1; ENSCSEG00000015865.1.
DR GeneTree; ENSGT00940000164418; -.
DR InParanoid; A0A3P8WDT2; -.
DR OMA; CSEEHGY; -.
DR Proteomes; UP000265120; Chromosome 4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 4.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR011651; Notch_ligand_N.
DR PANTHER; PTHR24033; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24033:SF151; PROTEIN EYES SHUT; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 4.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF07657; MNNL; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00179; EGF_CA; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 7.
DR PROSITE; PS01186; EGF_2; 6.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 2.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..672
FT /note="Delta-like protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018121501"
FT TRANSMEM 489..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 153..197
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 198..230
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 263..301
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 303..339
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 351..393
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 395..431
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 433..469
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 155..164
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 168..180
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 188..197
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 202..212
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 220..229
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 291..300
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 329..338
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 383..392
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 421..430
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 459..468
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 672 AA; 73411 MW; 5BA2C38592B787E5 CRC64;
MARLLLCCLL LLALSSGVFE LKIDSFASSR GICRSSSQSC QIFFRVCLKH SQDVINPEPP
CTYGTELTDI MDADANTISQ SAPIKVPFLF KWPGTFSLII EAWNAESTGP ESIENQNNLI
SRLATRRHLA VGEEWSQDVH FGDQSELRYS YHVVCNEHYH GESCSAYCRP RNDTFGHYTC
DEQGKRRCLD GWSGEYCSDA ICATGCSKNG FCESPGECVC RQGWQGALCD ECARHPGCLH
GTCQQPWQCN CKEGWGGLYC DQDLNYCTNH KPCKNGASCT NTGQGSYTCT CRPGFTGKDC
ESETNECDSN PCKNGGSCKN TAGGYSCRCP QGYTGSNCEK RLDRCSSNPC ANGTCQILCV
HSYTSYLLRA QCVDLGQRVT CRCRPGFSGP RCEINVDDCA SNPCRNGGTC VDGVNDFTCT
CTLGFTGKDC SVRDSPCDHF PCENGGTCFT HFTGPVCQCP LGFMGARCEY PVKVMPTTKP
LSQADQSPAL IAAIVLGLVT LTLLLCAAVF IVRQLRRGRE LRSITTSVKN DLEAVNNRNA
VIGGGGPNNG CLPGAAVSLR EKEVFLMSGG QLKVSNKDAA LVEKGSNMSI FKNKMADCNL
VNEEQHKTKS NKTCDSPIAV KDSRYCPVFI IPEQMEQCVF ATEVRTNSFK VFCFFLIINK
PCSSSRTLMT NL
//
