ID A0A3P8WEA8_CYNSE Unreviewed; 540 AA.
AC A0A3P8WEA8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Frizzled class receptor 10 {ECO:0000313|Ensembl:ENSCSEP00000025034.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000025034.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000025034.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
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DR AlphaFoldDB; A0A3P8WEA8; -.
DR STRING; 244447.ENSCSEP00000025034; -.
DR Ensembl; ENSCSET00000025366.1; ENSCSEP00000025034.1; ENSCSEG00000015991.1.
DR GeneTree; ENSGT00940000161861; -.
DR InParanoid; A0A3P8WEA8; -.
DR OMA; VMCEQVK; -.
DR Proteomes; UP000265120; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0042813; F:Wnt receptor activity; IEA:Ensembl.
DR GO; GO:0090504; P:epiboly; IEA:Ensembl.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF86; FRIZZLED-10; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..540
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018273566"
FT TRANSMEM 238..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 406..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..155
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 237..523
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 150..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..186
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 39..100
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 47..93
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 84..122
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 111..152
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 115..139
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 540 AA; 59860 MW; 2651C40701810367 CRC64;
MRSCARVNLL GALLVLCGGV GVSSAISSAD PDWSGEGRCQ RIVIPQCRDI GYNSTRMPNL
MGHDDQQEAA LELREFATLI RLGCHGHLRF FLCSLYAPMC TEQVSNPIPA CRLMCEQVRA
KCSPVLDHFN FPWPDSLDCS RLPTRNDPNH LCMEAPTNGS SDDAAPPRVS QTQPPDFRPP
PHLPGGGDRE LPLKDGGRKE GCANPGKFHF VAKSESCAPR CHPQVDVYWS RGDKRFSLVW
MSVWSVLCFA SSAFTVLTFL VDPGRFKYPE RPIVFLSVSY CVYSLGYLAR LAAGADGIAC
DRDAGVQYVV QEGLESAGCT AVFLVLYYFG MASSLWWVIL TLAWFLAAGK KWGHEAIEAR
SGYFHLAAWA VPAAKTVLIL VTRKVAGDEL TGLCYVGGMD AEALTGFVLV PLSCYLIVGT
SFLLSGFVSL FHIRRVMRTE GEDTDKLEKL MVRIGVFSVL YTVPAACVIA CYVYERLNVE
RCLPAGEMYQ NKMLKIFNIH SLNYDDASPP KYIEVYLIYI YSNINKPERG NVSQFTTEMF
//
